中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (1): 67-68.

• 综述 • 上一篇    下一篇

激光联合外用血管生成抑制剂治疗鲜红斑痣

苑凯华1,黄正2,黄巧冰3,廖元兴4   

  1. 1. 广州军区广州总医院激光整形中心
    2. Department of Radiation Oncology，University of Colorado Denver, Colorado, USA
    3. 南方医科大学病生教研室
    4. 广州军区广州总医院激光整形中心 广州市流花路111号广州军区总医院激光整形外科 510010
  • 收稿日期:2009-04-24 修回日期:2009-05-23 出版日期:2010-01-15 发布日期:2010-01-05
  • 通讯作者: 苑凯华 E-mail:yhlaser@126.com
  • 作者简介:

    从事激光整形外科12年，主要专业为激光在整形美容外科的应用，主要从事激光治疗色素性、血管性疾病，激光脱毛，激光整形美容手术，激光五官科疾病的治疗。博士期间的方向为血管性疾病的基础与临床。

     

Treatment of naevus flammeus with laser combined with topical angiogenesis inhibitor

  • Received:2009-04-24 Revised:2009-05-23 Online:2010-01-15 Published:2010-01-05
  • About author:my profession is laser treatment of pigmented lesion,vascular lesion,unwanted hair, laser cosmetic surgery,laser treatment of otorhinoaryngological disease. my major is the clinical and basic reseach of vascular disease  at doctoral period

PDF

385

赞

摘要：

鲜红斑痣是一种发生在真皮浅层的先天性毛细血管后微静脉扩张畸形。脉冲染料激光是目前治疗鲜红斑痣的标准方法，对各种不同类型的鲜红斑痣均能达到一定程度的褪色，但对大部分鲜红斑痣仍需多次治疗或采取综合疗法，并存在着治疗后色斑复发或加深的现象。近期有学者提出，鲜红斑痣激光成功治疗后的复发或色斑加深，是由于光热作用诱导的人体伤口正常修复反应而导致的新生血管增生，并尝试在激光治疗后辅助外用血管生成抑制剂，如咪喹莫特和雷帕霉素。本文结合多年临床治疗经验和文献资料简要介绍并讨论相关的新进展。

关键词: 激光, 伤口修复反应, 新生血管, 血管生成抑制剂, 鲜红斑痣

Abstract:

ABSTRACT Port wine stain (PWS) is a congenital cutaneous vascular malformation involving ectatic post-capillary venules. Current standard treatment for PWS is the pulsed dye laser (PDL), which can achieve a certain degree of color blanching in various types of PWS lesions. However, the majority of PWS lesions require multiple treatments or combination therapy. Some PWS lesions can recur or become darker after successful treatment. Recently, it has been proposed that this phenomenon might be initiated by neoangiogenesis that can be caused by photothermolysis via wound healing response. The combined use of laser irradiation and a topical application of an angiogenic inhibitor such as Imiquimod and Rapamycin, were evaluated in several pilot studies. This article will discuss rationales of using such a combination modality and highlight recent progress based on our clinical experience and published data.

Key words: laser, wound healing response, angiogenesis, angiogenic inhibitor, Port Wine Stain