关键词: HIF-1α;VEGF;Ang-2;妊娠;尖锐湿疣

Abstract:

Objective To investigate the expression and significance of hypoxia-inducible factor 1 alpha （HIF-1α），vascular endothelial growth factor （VEGF） and angiopoietin-2 （Ang-2） in tissues of condyloma acuminatum （CA） in pregnant women. Methods Tissue specimens were obtained from the lesions of 30 pregnant women with CA and 30 non-pregnant women with CA, and from the vulva of 15 normal pregnant women. By immunohistochemical staining，the expressions of HIF -1α，VEGF and Ang-2 were detected in these specimens. Results The expression rates of HIF -1α，VEGF and Ang-2 were 86.67%, 93.33% and 83.33% in pregnant women with CA, respectively, 63.33%, 66.67% and 53.33% in non-pregnant women with CA, respectively, and 0, 6.67% and 0 in normal women, respectively．Enhanced expressions of HIF -1α，VEGF and Ang-2 were observed in pregnant women with CA compared with the latter two groups （P < 0.05）. In pregnant women with CA, a significant correlation was noted between the expression of HIF -1α and VEGF （r = 0.412, P < 0.01） and between the expression of Ang-2 and VEGF （r = 0.460, P < 0.01）. Further more, the expression of HIF -1α，VEGF and Ang-2 positively correlated with each other in non-pregnant women with CA. Conclusion In tissues of CA in pregnant women, HIF-1α，Ang-2 and VEGF are over expressed, which may be related to angiogenesis.