中国特应性皮炎的研究现状与展望

doi:10.35541/cjd.20260077

中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (6): 505-511.doi: 10.35541/cjd.20260077

• 专家论坛·特应性皮炎 • 上一篇下一篇

中国特应性皮炎的研究现状与展望

李巍¹,姚煦²

¹复旦大学附属华山医院皮肤科，上海 200040；²中国医学科学院北京协和医学院，皮肤病医院过敏与风湿免疫科，南京 210042

收稿日期:2026-02-05 修回日期:2026-04-12 发布日期:2026-06-05
通讯作者: 李巍；姚煦 E-mail:liweiderma@fudan.edu.cn; dryao_xu@126.com
基金资助:
国家自然科学基金（82330098，82530099）

Research on atopic dermatitis in China: current status and future perspectives

Li Wei¹, Yao Xu²

¹Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China; ²Department of Allergy and Rheumatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Nanjing 210042, China

Received:2026-02-05 Revised:2026-04-12 Published:2026-06-05
Contact: Li Wei; Yao Xu E-mail:liweiderma@fudan.edu.cn; dryao_xu@126.com
Supported by:
National Natural Science Foundation of China（82330098，82530099）

摘要/Abstract

摘要： 【摘要】特应性皮炎（AD）是一种复杂的炎症性皮肤病。近20年来，我国AD患病率持续增长。因临床表现常呈现不典型特征，已有多种诊断标准被提出和验证。遗传学研究显示，中国AD患者既存在与高加索人群一致的易感基因位点，也存在独特的遗传位点。在发病机制上，皮肤微生物组在AD的发病中起重要作用，皮肤中的免疫细胞则是AD发病机制中的关键效应细胞，神经免疫机制也参与了AD炎症应答的发生发展。近年来，以生物制剂和Janus激酶抑制剂为代表的新型系统治疗药物在我国AD患者中展现出良好的疗效与安全性。我国学者在AD领域的研究推动了对该病的认识和疾病管理。

关键词: 皮炎, 特应性, 内型, 诊断, 发病机制, 微生物组, 炎症, 生物制剂, Janus激酶抑制剂

Abstract: 【Abstract】 Atopic dermatitis （AD） is a complex inflammatory skin disorder. Over the past two decades, the prevalence of AD in China has been continuously increasing. Due to the atypical clinical manifestations of AD commonly seen in Chinese patients, several diagnostic criteria have been proposed and validated. Genetic studies have revealed that Chinese patients with AD share some susceptible loci with Caucasian populations, and also harbor unique susceptible loci. Regarding pathogenesis, the skin microbiome plays an important role in the development of AD. Meanwhile, immune cells in the skin serve as key effector cells that orchestrate various functions in AD. Neuroimmune mechanisms are also involved in the initiation and progression of inflammatory responses in AD. In recent years, novel systemic treatments, represented by biologics and Janus kinase inhibitors, have demonstrated favorable efficacy and safety profiles in Chinese AD patients. Collectively, research advances in the pathogenesis and treatment of AD made by Chinese scholars have significantly improved the understanding and management of AD.

Key words: Dermatitis, atopic, Endotype, Diagnosis, Pathogenesis, Microbiome, Inflammation, Biologics, Janus kinase inhibitor

李巍姚煦. 中国特应性皮炎的研究现状与展望[J]. 中华皮肤科杂志, 2026,59(6):505-511. doi:10.35541/cjd.20260077

Li Wei¹, Yao Xu². Research on atopic dermatitis in China: current status and future perspectives[J]. Chinese Journal of Dermatology, 2026, 59(6): 505-511.doi:10.35541/cjd.20260077

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中国特应性皮炎的研究现状与展望

Research on atopic dermatitis in China: current status and future perspectives

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