中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (1): 74-76.doi: 10.35541/cjd.20240736

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真皮获得性斑状色素沉着症的诊疗难点及对策

项蕾红,徐中奕   

  1. 复旦大学附属华山医院皮肤科,上海  200040
  • 收稿日期:2024-12-31 修回日期:2025-08-12 发布日期:2026-01-06
  • 通讯作者: 项蕾红 E-mail:flora_xiang@vip.163.com
  • 基金资助:
    国家重点研发计划(2023YFC2509001)

Diagnosis and treatment of acquired dermal macular hyperpigmentation: challenges and strategies

Xiang Leihong, Xu Zhongyi    

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2024-12-31 Revised:2025-08-12 Published:2026-01-06
  • Contact: Xiang Leihong E-mail:flora_xiang@vip.163.com
  • Supported by:
    National Key Research and Development Program of China(2023YFC2509001)

摘要: 【摘要】 真皮获得性斑状色素沉着症是近年在色素沉着性皮肤病领域全新引入的术语,旨在统一过去分别被称为瑞尔黑变病、色素性接触性皮炎、色素性扁平苔藓、灰皮病(持久性色素异常性红斑)的疾病。这类疾病好发于面颈、躯干等部位,具有显著的损容性,对患者心理健康及社交造成严重影响。目前此类疾病临床上面临的主要问题在于病因及发病机制尚不明确,鉴别诊断困难,治疗难度大。基于此现状,本文提出瑞尔黑变病等真皮获得性斑状色素沉着症的诊疗难点,并分析潜在的对策。

关键词: 皮肤色素沉着, 真皮获得性斑状色素沉着症, 瑞尔黑变病, 诊断, 治疗, 斑贴试验, 光敏感性

Abstract: 【Abstract】 Acquired dermal macular hyperpigmentation has been newly introduced as a term in the field of pigmentary skin diseases in recent years, aiming to unify diseases previously classified separately as Riehl's melanosis, pigmented contact dermatitis, lichen planus pigmentosus, and ashy dermatosis (erythema dyschromicum perstans). These disorders predominantly affect areas such as the face, neck, and trunk, and are notably disfiguring, exerting a profound impact on patients′ psychological health and social life. Currently, the main clinical challenges in managing these conditions include their unclear etiology and pathogenesis, difficulties in differential diagnosis, and limited therapeutic efficacy. In light of this situation, this article outlines the diagnostic and therapeutic challenges associated with Riehl's melanosis and other types of acquired dermal macular hyperpigmentation, and provides potential countermeasure analysis.

Key words: Skin pigmentation, Acquired dermal macular hyperpigmentation, Riehl′s melanosis, Diagnosis, Therapy, Patch test, Photosensitivity

引用本文

项蕾红 徐中奕. 真皮获得性斑状色素沉着症的诊疗难点及对策[J]. 中华皮肤科杂志, 2026,59(1):74-76. doi:10.35541/cjd.20240736

Xiang Leihong, Xu Zhongyi . Diagnosis and treatment of acquired dermal macular hyperpigmentation: challenges and strategies[J]. Chinese Journal of Dermatology, 2026, 59(1): 74-76.doi:10.35541/cjd.20240736