中华皮肤科杂志

• 论著 • 上一篇    下一篇

HLA-DRB1，DQA1，DQB1基因单倍型与华东地区汉族人群白癜风的相关性

吴文育1, 汤芦艳1, 李剑1, 孟炜2, 傅雯雯1, 廖康煌1   

  1. 1. 复旦大学附属华山医院皮肤科, 上海, 200040;
    2. 复旦大学公共卫生学院流行病学教研室
  • 收稿日期:2006-06-29 出版日期:2007-06-15 发布日期:2007-06-15
  • 基金资助:
    中华医学会皮肤性病学分会皮肤科研究基金(2002年)

Association of HLA-DRB1, DQA1, DQB1 haplotypes with vitiligo in a Han population in East China

WU Wen-yu1, TANG Lu-yan1, LI Jian1, MENG Wei2, FU Wen-wen1, LIAO Kang-huang1   

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2006-06-29 Online:2007-06-15 Published:2007-06-15

PDF (PC)

160

赞

摘要： 目的 探讨HLA-DRB1、DQA1、DQB1基因单倍型与华东地区汉族人群白癜风的相关性。方法 采用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSOP)方法检测华东地区汉族白癜风患者HLA-DRB1、DQA1、DQB1位点的等位基因,运用遗传学群体与家系资料计算机分析系统3.0筛选并分析单倍型。结果 与正常人对照组比较,HLA-DRB1*09-DQA1*03-DQB1*0303单倍型频率显著增高(Pc=0.02,OR=2.542)。结论 在华东地区汉族人群中,HLA-DRB1*09-DQA1*03-DQB1*0303单倍型可能是白癜风的易感单倍型。

关键词: 单倍性, 白癜风, 基因, MHCⅡ类

Abstract: Objective To investigate the association of HLA-DRB1,DQA1,DQB1 haplotypes with vitiligo in a Han popultion in East China.Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1,DQA1 and DQB1 alleles by PCR-sequence specific oligonucleotide probes(SSOP)typing.Then,population and pedigree analysis programs(PPAP 3.0)was used to screen and analyze haplotypes.Results The frequency of the haplotype HLA-DRB1*09-DQA1*03-DQB1*0303 was signifi-cantly higher(Pc=0.02,OR=2.542)in the vitiligo patients than in the controls.Conclusions Our results suggest that a correlation exists between HLA-DRB1,DQA1,DQB1 haplotypes and vitiligo,and HLA-DRB1*09-DQA1*03-DQB1*0303 may be a susceptible haplotype for vitiligo in the Han population in East China.

Key words: Vitiligo, Genes, MHC classⅡ, Haploidy