中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (11): 1023-1027.doi: 10.35541/cjd.20191117

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日光光动力疗法在光线性角化病的临床应用进展

金双    黄丹    陈崑   

  1. 中国医学科学院、北京协和医学院皮肤病医院理疗科,南京  210042 
  • 收稿日期:2019-11-26 修回日期:2020-07-11 发布日期:2021-11-01
  • 通讯作者: 陈崑 E-mail:kunchen181@aliyun.com
  • 基金资助:
    国家自然科学基金(81872545);中国医学科学院医学与健康科技创新工程项目(CIFMS-2017-I2M-1-017)

Daylight photodynamic therapy for the treatment of actinic keratosis

Jin Shuang, Huang Dan, Chen Kun   

  1. Department of Physiotherapy, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2019-11-26 Revised:2020-07-11 Published:2021-11-01
  • Contact: Chen Kun E-mail:kunchen181@aliyun.com
  • Supported by:
    National Natural Science Foundation of China (81872545); CAMS Innovation Fund for Medical Sciences (CIFMS-2017-I2M-1-017)

摘要: 【摘要】 光线性角化病(AK)是与长期光暴露有关的一种皮肤癌前期损害,光动力疗法是其主要治疗方法之一。与传统光动力疗法相比,以日光作为光源的日光光动力疗法操作方便,疼痛感低,患者接受度高,但易受到天气等因素的影响,适用于头面部Ⅰ级或Ⅱ级光线性角化病的治疗,预处理、光敏剂、光照等均可能影响其疗效。本文主要阐述日光光动力疗法的优势,并介绍其操作方法,以帮助临床工作者选择最佳治疗方案。

关键词: 角化病, 光化性, 光化学疗法, 日光疗法, 治疗结果, 影响因素分析

Abstract: 【Abstract】 Actinic keratosis (AK) is a kind of precancerous skin lesions related to long-term light exposure, and photodynamic therapy is one of its main treatment methods. Compared with conventional photodynamic therapy (C-PDT), daylight photodynamic therapy (DL-PDT) with daylight as a light source has advantages of more convenient operation, less pain and higher patient acceptability, but it is liable to be affected by weather and other factors. DL-PDT is suitable for the treatment of grade Ⅰ or Ⅱ AK on the head and face, and its efficacy may be affected by pretreatment, photosensitizers, irradiation dose, etc. This review mainly elaborates the advantages of DL-PDT and introduces its operation methods to help clinicians choose the best treatment protocol for AK.

Key words: Keratosis, actinic, Photochemotherapy, Heliotherapy, Treatment outcome, Root cause analysis

引用本文

金双 黄丹 陈崑. 日光光动力疗法在光线性角化病的临床应用进展[J]. 中华皮肤科杂志, 2021,54(11):1023-1027. doi:10.35541/cjd.20191117

Jin Shuang, Huang Dan, Chen Kun. Daylight photodynamic therapy for the treatment of actinic keratosis[J]. Chinese Journal of Dermatology, 2021, 54(11): 1023-1027.doi:10.35541/cjd.20191117