NLRP3炎性小体与皮肤病

doi:10.35541/cjd.20190023

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (3): 236-238.doi: 10.35541/cjd.20190023

• 综述 • 上一篇

NLRP3炎性小体与皮肤病

陆豪杰宋秀祖

浙江中医药大学附属杭州市第三医院皮肤科 310009

收稿日期:2018-11-08 修回日期:2019-05-05 发布日期:2020-03-03
通讯作者: 宋秀祖 E-mail:songxiuzu@sina.com
基金资助:
国家自然科学基金;浙江省基础公益研究计划项目;杭州市科技计划项目

NLRP3 inflammasomes and skin diseases

Lu Haojie, Song Xiuzu

Department of Dermatology, Hangzhou Third Hospital, Zhejiang Chinese Medical University, Hangzhou 310009, China

Received:2018-11-08 Revised:2019-05-05 Published:2020-03-03
Contact: Song Xiuzu E-mail:songxiuzu@sina.com
Supported by:
National Natural Science Foundation of China;Zhejiang Basic Public Welfare Research Project;Hangzhou Science and Technology Planning Project

摘要/Abstract

摘要： 【摘要】 NLRP3炎性小体在固有免疫中发挥重要作用，通过活化胱天蛋白酶1诱导细胞因子白细胞介素（IL）-1β和IL-18的成熟和释放，参与多种宿主免疫和炎性反应。一旦机体对NLRP3炎性小体的调控失衡，则可能产生过量的IL-1β和IL-18，从而引发一系列炎症性疾病。NLRP3炎性小体活化在痤疮、银屑病、坏疽性脓皮病、多发性肌炎/皮肌炎、大疱性类天疱疮等皮肤病中发挥重要作用。本文综述NLRP3炎性小体在皮肤病中的研究进展。

关键词: 炎性体, 白细胞介素1β, 白细胞介素18, 皮肤疾病, NLRP3

Abstract: 【Abstract】 NOD-like receptor protein 3 （NLRP3） inflammasomes play an important role in innate immunity. It can induce the maturation and release of cytokines interleukin （IL）-1β and IL-18 by activating caspase-1, and participate in a variety of host immunoinflammatory responses. Once the regulation of NLRP3 inflammasomes is unbalanced, excess IL-1β and IL-18 may be produced, triggering a series of inflammatory diseases. NLRP3 inflammasome activation plays important roles in skin diseases such as acne, psoriasis, pyoderma gangrenosum, polymyositis/dermatomyositis and bullous pemphigoid. This review summarizes research progress in NLRP3 inflammasomes in skin diseases.

Key words: Inflammasomes, Interleukin-1beta, Interleukin-18, Skin diseases, NLRP3

陆豪杰宋秀祖. NLRP3炎性小体与皮肤病[J]. 中华皮肤科杂志, 2020,53(3):236-238. doi:10.35541/cjd.20190023

Lu Haojie, Song Xiuzu. NLRP3 inflammasomes and skin diseases[J]. Chinese Journal of Dermatology, 2020, 53(3): 236-238.doi:10.35541/cjd.20190023

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NLRP3炎性小体与皮肤病

NLRP3 inflammasomes and skin diseases

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