中华皮肤科杂志 ›› 2015, Vol. 48 ›› Issue (1): 53-54.

• 研究报道 • 上一篇    下一篇

寻常型天疱疮患者血清骨桥蛋白的检测

索桂英1,2,付萍3   

  1. 1. 昆明医学院第二附属医院
    2. 淄博市中西医结合医院
    3. 昆明医科大学第二附属医院风湿免疫科
  • 收稿日期:2014-04-09 修回日期:2014-06-19 发布日期:2019-06-12
  • 通讯作者: 付萍 E-mail:cinafuping@hotmail.com
  • 基金资助:
    人脐血间充质干细胞治疗天疱疮疗效及对Th17/Treg影响的研究

Detection of serum osteopontin in patients with pemphigus vulgaris

Gui-Ying SUO,fuping pingping   

  • Received:2014-04-09 Revised:2014-06-19 Published:2019-06-12
  • Contact: fuping pingping E-mail:cinafuping@hotmail.com

PDF

5

摘要： 目的 探讨寻常型天疱疮（PV）患者血清中骨桥蛋白在PV发病中的作用。 方法 用酶联免疫吸附试验对31例寻常型天疱疮患者和35例健康对照组血清骨桥蛋白的浓度进行测定。用SPSS17.0及Excell统计软件对数据进行处理。 结果 PV患者血清骨桥蛋白的表达水平显著高于健康对照组（P < 0.01）。皮肤黏膜同时受累患者血清骨桥蛋白水平高于仅皮肤受累组（P < 0.05）。合并感染组血清骨桥蛋白水平高于未合并感染组（P < 0.01）； PV患者的血清骨桥蛋白水平与抗Dsg3抗体呈正相关（rs = 0.489，P < 0.01）。 结论 骨桥蛋白在PV患者血清中高表达，特别是皮肤黏膜同时受累的患者，且与天疱疮抗体滴度呈正相关。

关键词: 天疱疮, 骨桥蛋白, 酶联免疫吸附测定

Abstract: Suo Guiying, Fu Ping*. *Department of Dermatology/Rheumatology, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China Corresponding author: Fu Ping, Email: cinafuping@hotmail.com 【Abstract】 Objective To investigate the role of serum osteopontin in the occurrence of pemphigus vulgaris （PV）. Methods Enzyme-linked immunosorbent assay was conducted to determine serum levels of osteopontin in 31 patients with PV and 35 healthy human controls. Statistical analysis was carried out by t test and Spearman rank correlation analysis with the SPSS 17.0 software and Excel. Results Serum levels of osteopontin were significantly higher in patients with PV than in healthy controls （P < 0.01）, in patients with mucocutaneous involvement than in those with only cutaneous involvement （P < 0.05）, and in patients with complicated infections than in those without （P < 0.01）. There was a positive correlation between serum levels of osteopontin and anti-Dsg3 antibody in patients with PV （rs = 0.489, P < 0.01）. Conclusions Serum levels of osteopontin are increased in patients with PV, especially in those with mucocutaneous involvement, and positively correlated with PV-related antibody titers.

Key words: Pemphigus, Osteopontin, Enzyme-linked immunosorbent assay

引用本文

索桂英 付萍. 寻常型天疱疮患者血清骨桥蛋白的检测[J]. 中华皮肤科杂志, 2015,48(1):53-54. doi:

Gui-Ying SUO fuping pingping. Detection of serum osteopontin in patients with pemphigus vulgaris[J]. Chinese Journal of Dermatology, 2015, 48(1): 53-54.doi: