关键词: 蕈样肉芽肿, 纤维瘤, 真皮, 泼尼松

Abstract: Li Baizhou, Chen Qin, Chen Jisu, Wang Ping. Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China Corresponding author: Wang Ping, Email: wpycg@medmail.com.cn 【Abstract】 A 45-year-old female was admitted to the hospital for a 15-year history of miliary papules all over the body surface with severe skin dryness and pruritus. Six years prior to the presentation, she suffered from gradual loss of head, axillary and pubic hair as well as skin laxity in the axillary, inguinal and intermammary region, and diagnosed with granulomatous slack skin associated with folliculotropic granuloma fungoides. Then, she received six sessions of chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone （CHOP）. Additionally, long-term oral prednisone （30 － 40 mg per day） was administrated before and after the diagnosis. Half a year prior to the presentation, more than 10 elevated nodules gradually appeared in bilateral lower limbs, chest and back. Pathology of one of the nodules revealed a well-defined nodular lesion without capsules in the subdermis, composed of spindle and oval cells arranged in a storiform pattern as well as a small number of giant cells without obvious atypia, which was suggestive of dermatofibroma. The final diagnosis was multiple eruptive dermatofibromas. The patient was managed with a watch-and-wait strategy, and follow-up was under way.

Key words: Granuloma fungoides, Fibroma, Dermis, Prednisone