中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (11): 826-828.

• 研究报道 • 上一篇    下一篇

儿童节段型白癜风的临床特点分析

李阳1,祝逸平2,许爱娥3   

  1. 1. 杭州市第三人民医院皮肤科
    2. 杭州市第三人民医院
    3. 安徽医科大学附属杭州市第三人民医院皮肤科
  • 收稿日期:2012-11-21 修回日期:2013-08-29 出版日期:2013-11-15 发布日期:2013-11-01
  • 通讯作者: 许爱娥 E-mail:xuaiehz@msn.com

Clinical analysis of segmental vitiligo in children

1, 1,   

  • Received:2012-11-21 Revised:2013-08-29 Online:2013-11-15 Published:2013-11-01

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摘要： 【摘要】 目的 了解儿童节段型白癜风的临床特点及其病情变化。 方法 采用问卷调查方法收集2011年10月至2012年7月于我科门诊就诊的170例儿童节段型白癜风患者的临床流行病学资料，对照组为发病年龄在18岁以上的174例成人节段型白癜风患者。用SPSS16.0软件包对资料进行分析。 结果 儿童节段型白癜风患者170例，其中男108例占63.5%，女62例占36.5%，男女性别比例与成年患者组相比，差异有统计学意义（χ2 = 14.44，P < 0.05）。82.9%的儿童患者以局限型起病，成人患者为76.4%。儿童患者中76.5%半年内由局限型发展成节段型，成人为63.9%。在以局限型起病的患者中，进展半年后稳定的儿童患者占71.6%，成人患者为67.3%；以节段型起病的患者中，进展1个月后稳定的儿童患者占62.1%，成人患者为41.5%，两组比较，χ2 = 8.39，P < 0.01。44.1%的儿童患者初发于头面部，成人患者为56.9%。以单一神经节段起病的儿童患者占94.7%，成人患者为86.8%，两组比较，χ2 = 0.04，P > 0.05。儿童患者伴白发（χ2 = 15.88，P < 0.01）、自身免疫性疾病（χ2 = 5.62，P < 0.05）、有白癜风家族史的比例（χ2 = 6.66，P = 0.01）均低于成年患者组。 结论　儿童节段型白癜风以男性多见，主要以局限型起病，70%以上的患者进展半年后病情稳定。

关键词: 白癜风, 儿童, 临床研究

Abstract: LI Yang, ZHU Yi-ping, XU Ai-e. Department of Dermatology, Third People′s Hospital of Hangzhou, Hangzhou 310009, China Corresponding author: XU Ai-e, Email: xuaiehz@msn.com 【Abstract】 Objective To analyze the clinical features and evolution of segmental vitiligo in children. Methods A standardized questionnaire was used to clinically investigate segmental vitiligo in 170 children aged < or = 12 years and 174 adults with an age of onset > 18 years. Data analysis was done by the software SPSS16.0. Results The female to male ratio was 108 ∶ 62 in the 170 child patients, significantly different from that in the adult patients （χ2 = 14.44, P < 0.05）. Localized vitiligo occurred as the initial presentation in 82.9% （141/170） of the children and 76.4% （133/174） of the adults, and progressed into segmental vitiligo in half a year in 76.5% of the 141 children and 63.9% of the 133 adults. Vitiligo entered the quiescent stage after half-a-year progression in 71.6% of the children and 67.3% of the adults with localized vitiligo as the initial presentation, and after one-month progression in 62.1% of the children and 41.5% of the adults with segmental vitiligo as the first presentation （χ2 = 8.39, P < 0.01）. Head and face were affected at the onset of segmental vitiligo in 44.1% of the childhood cases and 56.9% of the adult cases. Single nerve segments were involved at the onset in 94.7% of the child patients and 86.8% of the adult patients （χ2 = 0.04, P > 0.05）. The proportions of patients with white hairs, autoimmune diseases, and family history were significantly lower in the child patients than in the adult patients （χ2 = 15.88, 5.62, 6.66 respectively, all P < 0.05）. Conclusions Childhood-onset segmental vitiligo shows a predilection for males, usually presents as localized vitiligo at the onset, and becomes quiescent after half-a-year progression in more than 70% of patients.

Key words: Clinical Study