中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (9): 543-545.

• 论著 • 上一篇    下一篇

尖锐湿疣皮损活化抗原CD69、CD38、HLA-DR的表达及其意义

郭庆1, 曾凡钦2, 曾韵洁2, 李海刚2   

  1. 1. 中山大学附属第二医院皮肤科, 广州 510120;
    2. 中山大学附属第二医院病理科
  • 收稿日期:2006-12-26 出版日期:2007-09-15 发布日期:2007-09-15
  • 通讯作者: 曾凡钦, email:fqzeng@21cn.com E-mail:fqzeng@21cn.com

Expressions of activated antigens CD69,CD38,and HLA-DR in keratinocytes and mononuclear cells of condyloma acuminatum lesions and their significance

GUO Qing1, ZENG Fan-qin2, ZENG Yun-jie2, LI Hai-gang2   

  1. Department of Dermatology, Second Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510120, China
  • Received:2006-12-26 Online:2007-09-15 Published:2007-09-15

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摘要： 目的 探讨活化抗原CD69,CD38,HLA-DR在尖锐湿疣(CA)皮损角质形成细胞(KC)和真皮浸润单核细胞(MNC)表达的变化.方法 免疫组化方法检测CA30例初发患者、20例复发患者皮损和15例正常人包皮KC和真皮浸润MNC上CD69,CD38,HLA-DR的表达并进行对比.结果 CA患者初发组和复发组皮损KC的CD69,CD38,HLA-DR阳性表达率分别为93.3%和90%、933%和90%、100%和100%,真皮浸润MNC的CD69,CD38,HLA-DR阳性表达率分别为0和0、66.7%和40%、76.7%和70%,正常人对照组均不表达.初发组和复发组皮损KC和真皮浸润MNC的CD69,CD38,HLA-DR表达强度比较显示,初发组明显高于复发组(P<0.05).结论 CA患者局部细胞免疫处于高水平的激活状态,这种免疫激活状态在抗病毒感染中有着一定的作用.

关键词: 尖锐湿疣, 抗原, CD69, 抗原, CD38, HLA-DR抗原

Abstract: Objective To investigate the expression of activated antigens CD69,CD38,and HLA-DR in keratinocytes(KCs) and mononuclear cells(MNC) of condyloma acuminatum(CA) lesions.Methods Biopsy specimens were obtained from 30 patients with primary CA,20 patients with recurrent CA and 15 normal human controls.The expression of CD69,CD38,and HLA-DR was measured using immunohistochemical technique.Results The positivity rates of CD69,CD38,and HLA-DR were 93.3%, 93.3% and 100% respectively in KCs of lesions from primary CA,90%,90% and 100% respectively in those from recurrent CA,0,66.7% and 76.7% respectively in MNC of lesions from primary CA,0,40% and 70% respectively in those from recurrent CA.None of the three antigens was expressed in the normal controls. The expression intensity of these three antigens was significantly higher in lesions from primary CA than in those from recurrent CA(all P<0.05).Conclusion The local cellular immunity is in a highly active status in CA patients,which may play a certain role in antiviral immunity.

Key words: Condylomata acuminata, Antigens,CD69, Antigens,CD38, HLA-DR antigens