中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (1): 10-12.

• 论著 • 上一篇    下一篇

特应性皮炎的部分嗜天青颗粒缺陷

薛筑云1, 余美玲1, 程宝庾2, 吕湘琴1, 黄允飞1   

  1. 1. 南京医学院附属第一医院皮肤科, 210029;
    2. 南京医学院电镜室
  • 收稿日期:1992-01-28 修回日期:1992-05-16 出版日期:1993-02-15 发布日期:1993-02-15
  • 基金资助:
    国家自然科学基金资助项目

Partial Azurophilic Granule Deficiency in Two Patieats with Atopic Disease

XUE Zhu-Yun1, YU Mei-Ling1   

  1. The First Teaching Hospital, Nanjing Medical College, Nanjing 210029
  • Received:1992-01-28 Revised:1992-05-16 Online:1993-02-15 Published:1993-02-15

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摘要： 研究2例特应性疾病和双亲的中性粒细胞.超微结构示正名常嗜天青颗粒(AG)明显减少,出现较多低电子密度异常AG(例1);多量次级溶酶体,内含降解不全物质,呈"髓鞘质样膜"图像(例2).光镜细胞化学示2例的髓过氧化物酶(MPO)和酸性磷酸酶活性均显著低于正常值.电镜细胞化学证实AG的MPO反应产物短缺和AG分布异常.双亲或其一方中性粒细胞有类似改变.本研究提示,遗传性中性粒细胞AG的MPO和溶脑体酶峡陷,被吞噬的物质降解不全,导致抗原性物质蓄积,成为特应性疾病重要始动病因.

关键词: 中性粒细胞, 嗜天青颗粒, 缺陷症, 特应性疾病

Abstract: The neutrophils from 2 patients with atopic disease and parents were studied. Ultrasiructonally, normal azurophilic granules (AG) were decreased obviously, a number of abnormal (AG)with low electron-density (Case 1) and secondary lysosomes with "myelinoid membrantes" figures (Case 2) were found.

Key words: Neutrophil, Azurophilic, gzanuie, laeficiency, Atopic, discasc