中华皮肤科杂志

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血浆骨桥蛋白水平与系统性红斑狼疮活动性的关系

楼波, 吕晶, 郑敏   

  1. 浙江大学医学院附属第二医院皮肤科 杭州 310009
  • 收稿日期:2005-09-26 出版日期:2006-04-15 发布日期:2006-04-15
  • 通讯作者: 郑敏, email:minz@zju.edu.cn E-mail:minz@zju.edu.cn

The relationship between osteopontin plasma concentration and disease activity in systemic lupus erythematosus

LOU Bo, LU Jing, ZHENG Min   

  1. Department of Dermatology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China
  • Received:2005-09-26 Online:2006-04-15 Published:2006-04-15

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摘要： 目的 探讨血浆骨桥蛋白与系统性红斑狼疮(SLE)活动程度的关系。方法 采用ELISA方法检测28例健康人与38例SLE患者血浆骨桥蛋白水平,以分析其与SLE活动性变化关系。结果 SLE患者血浆骨桥蛋白水平(420±203)ng/mL明显高于正常对照组(73±14)ng/mL,P<0.001;SLE蛋白尿组(623±88)ng/mL明显高于非蛋白尿组(288±135)ng/mL,P<0.001;活动组(529±143)ng/mL明显高于非活动组(185±66)ng/mL,P<0.001;糖皮质激素治疗后血浆骨桥蛋白水平(142±22)ng/mL与治疗前水平(556±130)ng/mL相比,差异有统计学意义(P<0.001);关节炎组(489±153)ng/mL与非关节炎组(375±222)ng/mL之间差异无统计学意义,P>0.05。血浆骨桥蛋白水平与SLE DAI呈正相关,r=0.93,P<0.001;与C3呈负相关,r=-0.49,P<0.05;与ANA滴度、血细胞沉降率、C4水平无相关性(P>0.05)。结论 血浆骨桥蛋白水平变化与SLE活动程度、肾脏损害及疾病进展有关。

关键词: 红斑狼疮, 系统性, 骨桥蛋白, 酶联免疫吸附测定

Abstract: Objective To investigate the relationship between plasma concentration of osteopontin (OPN) and disease activity in systemic lupus erythematosus (SLE).Methods The plasma concentration of OPN in 28 healthy controls and 38 SLE patients was measured by enzyme-linked immunosorbent assay.Results The plasma concentration of OPN was significantly higher in SLE patients compared to that in the healthy controls (420±203 ng/mL vs 73±14 ng/mL,P<0.001),in the patients with proteinuria compared to that in the patients without proteinuria (623±88 ng/mL vs 288±135 ng/mL,P<0.001),in the patients with active disease compared to that in those with inactive disease (529±143 ng/mL vs 185±66ng/mL,P<0.001),in the patients before treatment compared to that in the patients after treatment (556±130 ng/mL vs 142±22 ng/mL,P<0.001).The plasma concentration of OPN in patients with arthritis was not different from those without arthritis (489±153 ng/mL vs 375±222 ng/mL,P>0.05).Plasma concentration of OPN showed a significant positive correlation with systemic lupus erythematosus disease activity index (SLEDAI) (r=0.93,P<0.001),but a significant negative correlation with serum C3 level (r=-0.49,P<0.05).There was no correlation between plasma concentration of OPN and antinuclear antibody titre,erythrocyte sedimentation rate,or serum level of C4.MConclusions These data show that plasma OPN level has some correlation with the SLE activity,renal damage and progression or amelioration of SLE.OPN could be involved in the pathogenesis of SLE.

Key words: Lupus erythematosus,systemic, Osteopontin, Enzyme-linked immunosorbent assay