中华皮肤科杂志

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山东汉族系统性红斑狼疮与HLA—DRB1等位基因的相关性

周盛基1, 杨宝琦1, 张福仁1, 田洪青1, 朱传福2, 宋永红2   

  1. 1. 山东省皮肤病性病防治研究所 济南 250022;
    2. 山东省血液中心 济南 250022
  • 收稿日期:2006-01-16 出版日期:2006-04-15 发布日期:2006-04-15
  • 通讯作者: 张福仁, email:zhangfuren@hotmail.com E-mail:zhangfuren@hotmail.com
  • 基金资助:
    山东省科技攻关计划基金(031050116)

Association of HLA-DRB1 alleles with systemic lupus erythematosus in Hart people in Shandong province

ZHOU Sheng-ji1, YANG Bao-qi1, ZHANG Fu-ren1, TIAN Hong-qing1, ZHU Chuan-fu2, SONG Yong-hong2   

  1. Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China
  • Received:2006-01-16 Online:2006-04-15 Published:2006-04-15

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摘要： 目的 探讨山东汉族系统性红斑狼疮(SLE)的发生与HLA-DRB1等位基因间的关系。方法 应用Luminex100流式分析仪,检测42例SLE患者和98例健康人对照14种HLA-DRB1等位基因。结果 SLE患者中检出12种HLA-DRB1等位基因,对照组中检出13种。其中HLA-DRB1*07等位基因与SLE呈强正相关,x2=9.643,P=0.002,Pc=0.028,RR=2.728,EF=0.204。HLA-DRB1*15等位基因与SLE亦有关联,x2=4.059,P=0.044,RR=1.84,Pc=0.0618。结论 HLA-DRB1*07可能是山东汉族SLE的易感基因。

关键词: 红斑狼疮, 系统性, HLA-DRB1抗原, 等位基因

Abstract: Objective To explore the association of HLA-DRB1 alleles with genetic susceptibility to systemic lupus erythematosus (SLE) in Hart people in Shandong province.Methods Blood samples were collected from 42 SLE patients and 98 healthy controls for PCR and hybridization.Then,Luminex100 fluoroanalyzer was used to analyze the distribution of HLA-DRBI alleles.Results Twelve kinds of HLA-DRB1 alleles were found in SLE specimens,and 13 in the control specimens.HLA-DRB1*07 alleles had significantly positive association with SLE (x2=9.643,P=0.002,Pc=0.028,RR=2.728,EF=0.204).HLA-DRB1*15 alleles also positively associated with SLE (x2=4.059,P=0.044,Pc=0.0618,RR=1.84).Conclusion HLA-DRB1*07 could possibly be the susceptibility genes for SLE in Han people in Shandong province.

Key words: lupus erythematosus,systemic, HLA-DRB1 antigens, Alleles