中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (4): 222-224.

• 论著 • 上一篇    下一篇

斑秃病人IL2产生缺陷的机理探讨

郭实士, 刘作明, 李立新   

  1. 湖南医科大学免疫研究室, 长沙, 410078
  • 收稿日期:1989-10-30 修回日期:1990-06-28 出版日期:1991-08-15 发布日期:1991-08-15
  • 基金资助:
    国家自然科学基金资助项目

Mechanism of defect of IL-2 prodnction in patients with alopecia areats

GUO Shi-Shi, LIU Zuo-Ming   

  1. Research Labora tory of Immunology, Hunan Medical University, Changsha
  • Received:1989-10-30 Revised:1990-06-28 Online:1991-08-15 Published:1991-08-15

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摘要： 旨在探讨斑秃病人外周血单个核细胞产生IL2活性异常的原因,发现病人IL2活性明显低于献血员.病人粘附细胞(MΨ)能有异常,病人MΨ分泌的IL1水平不低于献血员,但外源性PGE2可抑制病人IL2活性,MΨ数量变化似乎影响不大.病人外周血淋巴细胞在体外静置24小时后,IL2活性恢复正常,且至少可持续72小时,其原因及意义有待探讨.

Abstract: The IL-2 lovel of PBMC production on 25 patzents with alopecia areata (AA).frond decreased significantly in comparison with 35 normal donors (ND)(68.2+26.0U/ml, 102.4+23.7U/ml respectively)P<0.0005. When the macrophases of ND were added to the PBLC of AA patients, the IL-2 activity increased significantly, the level of IL-2 dropped when the macrophages of AA patients were put into the PBLC of ND. These results imply that the function of macrophages is abnortrtal in patients with AA. The level of macrophage production IL-1 activity was very rose (P>0.5) both in ND and AA. After extra PGE2 was added into PSMC (ND or AA), the resin is showed that PGF2 down-regulated IL-2 in ND and, in a lesser extent, in AA. On the contrary, after indomethacin, a PGE2 antagonist, was put into P13MC, the results indicated that the drug up-regulated IL-2 in patients and, in a lesser extent, in ND. Put the PBLC of AA in vitro for 24 hours or mare the IL-2 activity restored to normal at least for 72 hours, the cause and significance remain to be studied.