中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (4): 219-221.

• 论著 •    下一篇

白细胞介素1、肿瘤坏死因子α和粒细胞/巨噬细胞集落刺激因子对人体表皮郎格罕细胞表达CD1a表面抗原的影响

丁铁刚1, 邱丙森1, Stolenilt SA2, 阎淑玲1, 王晓梅3, Longley J2, Edelson RL2   

  1. 1. 上海医科大学皮肤病学研究所皮肤病研研究室, 240440;
    2. 美国耶会大学医学院皮肤科;
    3. 新疆维吾尔故自治区人民医院皮肤科
  • 收稿日期:1990-02-17 修回日期:1990-08-03 出版日期:1991-08-15 发布日期:1991-08-15
  • 基金资助:
    国家自然科学基金资助课题

Effects of interleukin-1, tumor necrosis factor-α and granulacyte/macrophage colony-stimulating factor on the expression of CDla earface antigen of human epidermal Langerhans cells

DING Tie-Gang1   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai
  • Received:1990-02-17 Revised:1990-08-03 Online:1991-08-15 Published:1991-08-15

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摘要： 报道白细胞介素1(IL1).肿瘤坏死因子(TNF).和粒细胞/巨吞细胞集落激因子(GM-CSF)对体外培荞人体麦皮郎格罕细胞(LC)表达CD1a(OKT6)表面抗原的影响.实验结果发现TNFα特别是IL1具有促使或维持LC对CD1a表面杭原的表达功能,GM-CSF则可抑制LC表达CD1a表面抗原的功能.本实验也证明体外培养LC在不受任何细胞因子影响时,难于成活,基于CD1a作为LC的特异性表面抗原,对LC的功能具有重要作用.为更好地研究CD1a的功能以及上述3种细胞因子对LC表达CD1a表面抗原的作用和机理,最好能在体外建立维持LC表达CD1a二表面抗原的细胞模型,以便作进一步研究.

Abstract: This paper reports the experimental results on the effects of interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and granulocyte/macrophage colony-stimulating factor (GMCSF) on the expression of CDla surface antigen of human epidermal Langerhans cells (LC) cultured in vitro. We discovered or iat IL-1 and TNF-α migkxt promote or maintain the expression of CDla surface antigen of LCGM-CSF might suppress the function of LC expressing CDla surface antigen.This experiment alsa proved that in the absence of any cytokine the LC cultured in vitro could not be kept alive easily. Because CDla is a specific surface antigen of LC it is important For the function of LC. It had better establish LC model maintaining the exprestion of CDla for further study on the function of CDla. and the Effecrtc and mechanism of the above three cytokines on the expression of CDla surface antigen of LC.