真皮获得性斑状色素沉着诊疗进展

doi:10.35541/cjd.20240734

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (9): 873-877.doi: 10.35541/cjd.20240734

真皮获得性斑状色素沉着诊疗进展

王琛丁玥岑董雅琦张成锋项蕾红徐中奕

复旦大学附属华山医院皮肤科，上海 200040

收稿日期:2024-12-31 修回日期:2025-08-02 发布日期:2025-09-01
通讯作者: 徐中奕 E-mail:jennyx_1222@sina.com
基金资助:
国家重点研发计划（2023YFC2509001）

Diagnosis and treatment of acquired dermal macular hyperpigmentation

Wang Chen, Ding Yuecen, Dong Yaqi, Zhang Chengfeng, Xiang Leihong, Xu Zhongyi

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2024-12-31 Revised:2025-08-02 Published:2025-09-01
Contact: Xu Zhongyi E-mail:jennyx_1222@sina.com
Supported by:
National Key Research and Development Program of China（2023YFC2509001）

摘要/Abstract

摘要： 【摘要】真皮获得性斑状色素沉着是指一组以灰黑色斑疹、斑片为主要临床表现，且色素沉积主要位于真皮层的疾病组，包括瑞尔黑变病、色素性扁平苔藓和持久性色素异常性红斑/灰皮病。鉴于这组疾病在皮损形态学和病理组织学特征上存在高度相似性，近年来学界提出"真皮获得性斑状色素沉着"这一新的疾病分类术语，以实现对这些疾病的整合与统一界定。本文从临床特点、皮肤镜表现、病理学特征、治疗进展等方面，详细介绍这组疾病的诊疗进展。

关键词: 皮肤色素沉着, 真皮获得性斑状色素沉着, 瑞尔黑变病, 色素性扁平苔藓, 持久性色素异常性红斑, 灰皮病

Abstract: 【Abstract】 Acquired dermal macular hyperpigmentation （ADMH） is a group of diseases clinically characterized by grayish-black macules and patches, with pigment predominantly deposited in the dermis. ADMH includes Riehl's melanosis, lichen planus pigmentosus, and erythema dyschromicum perstans/ashy dermatosis. In light of the remarkable similarities in both morphological and histopathological characteristics among this group of diseases, the academic community has recently proposed the new nosological term "acquired dermal macular hyperpigmentation" to achieve integration and unified classification of these related disorders. This review comprehensively elaborates on advances in the diagnosis and treatment of ADMH, including clinical manifestations, dermoscopic findings, pathological characteristics, and treatment progress.

Key words: Skin pigmentation, Acquired dermal macular hyperpigmentation, Riehl's melanosis, Lichen planus pigmentosus, Erythema dyschromicum perstans, Ashy dermatosis

王琛丁玥岑董雅琦张成锋项蕾红徐中奕. 真皮获得性斑状色素沉着诊疗进展[J]. 中华皮肤科杂志, 2025,58(9):873-877. doi:10.35541/cjd.20240734

Wang Chen, Ding Yuecen, Dong Yaqi, Zhang Chengfeng, Xiang Leihong, Xu Zhongyi. Diagnosis and treatment of acquired dermal macular hyperpigmentation[J]. Chinese Journal of Dermatology, 2025, 58(9): 873-877.doi:10.35541/cjd.20240734

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真皮获得性斑状色素沉着诊疗进展

Diagnosis and treatment of acquired dermal macular hyperpigmentation

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