吉非替尼引起头皮糜烂脓疱性皮病样疹1例

doi:10.35541/cjd.20200221

中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (3): 253-254.doi: 10.35541/cjd.20200221

吉非替尼引起头皮糜烂脓疱性皮病样疹1例

王小坡孙建方

中国医学科学院北京协和医学院皮肤病医院病理科，南京 210042

收稿日期:2020-03-09 修回日期:2020-09-05 发布日期:2022-03-03
通讯作者: 孙建方 E-mail:fangmin5758@aliyun.com
基金资助:
中国医学科学院医学与健康科技创新工程项目（2017-I2M-1-017）；南京市国家级临床医学中心培育计划项目（2019060001）

A case of erosive pustular dermatosis-like eruption of the scalp caused by gefitinib

Wang Xiaopo, Sun Jianfang

Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Received:2020-03-09 Revised:2020-09-05 Published:2022-03-03
Contact: Sun Jianfang E-mail:fangmin5758@aliyun.com
Supported by:
CAMS Innovation Fund for Medical Sciences（2017-I2M-1-017）; Nanjing Incubation Program for National Clinical Research Center （2019060001）

摘要/Abstract

摘要： 患者男，68岁。因头部红斑、脓疱、糜烂伴脱发半年就诊。患者8个月前因刺激性咳嗽、痰中带血，在当地医院确诊为右上肺腺癌ⅢA期（T3N1M0），给予表皮生长因子受体（epidermal growth factor receptor，EGFR）抑制剂——吉非替尼治疗，初始剂量为250 mg/d。2个月后患者发现头部出现红斑、脓疱、糜烂，伴脱发……

王小坡孙建方. 吉非替尼引起头皮糜烂脓疱性皮病样疹1例[J]. 中华皮肤科杂志, 2022,55(3):253-254. doi:10.35541/cjd.20200221

Wang Xiaopo, Sun Jianfang. A case of erosive pustular dermatosis-like eruption of the scalp caused by gefitinib[J]. Chinese Journal of Dermatology, 2022, 55(3): 253-254.doi:10.35541/cjd.20200221

［1］	张晓琳, 李辉, 叶思款. 吉非替尼片致头部脓疱疹一例［J］. 中国药物与临床, 2010,10（4）:384. doi: 10.3969/j.issn.1671⁃2560. 2010.04.064.
［2］	Starace M, Loi C, Bruni F, et al. Erosive pustular dermatosis of the scalp: clinical, trichoscopic, and histopathologic features of 20 cases［J］. J Am Acad Dermatol, 2017,76（6）:1109⁃1114.e2. doi: 10.1016/j.jaad.2016.12.016.
［3］	Lacouture ME, Anadkat MJ, Bensadoun RJ, et al. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor⁃associated dermatologic toxicities［J］. Support Care Cancer, 2011,19（8）:1079⁃1095. doi: 10.1007/s00520⁃011⁃1197⁃6.
［4］	Toda N, Fujimoto N, Kato T, et al. Erosive pustular dermatosis of the scalp⁃like eruption due to gefitinib: case report and review of the literature of alopecia associated with EGFR inhibitors［J］. Dermatology, 2012,225（1）:18⁃21. doi: 10.1159/000341528.
［5］	Fukui T, Kitamura H, Harada K, et al. Trichoscopic findings of erosive pustular dermatosis of the scalp associated with gefitinib［J］. Case Rep Dermatol, 2017,9（2）:44⁃49. doi: 10.1159/00047 5543.

吉非替尼引起头皮糜烂脓疱性皮病样疹1例

A case of erosive pustular dermatosis-like eruption of the scalp caused by gefitinib

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 5

相关文章 0

Metrics

本文评价

推荐阅读 10