中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (1): 30-32.

• 论著 • 上一篇    下一篇

慢性荨麻疹发作期与缓解期凝血状态、补体以及炎症标志物水平的改变

梁碧华1,李润祥1,林路洋1,李振洁2,肖常青2,朱慧兰3   

  1. 1. 广州市皮肤病防治所
    2.
    3. 广州市皮肤防治所
  • 收稿日期:2013-01-21 修回日期:2013-03-10 发布日期:2014-01-01
  • 通讯作者: 朱慧兰 E-mail:zhlhuilan@126.com
  • 基金资助:
    广东省自然科学基金;广州市医药卫生科技项目

Determination of coagulation status as well as circulating levels of complement and inflammation markers in patients with chronic urticaria during acute attack and in remission stage

  • Received:2013-01-21 Revised:2013-03-10 Published:2014-01-01
  • Contact: huilan zhu E-mail:zhlhuilan@126.com

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摘要： 【摘要】 目的 探讨凝血因子、抗凝因子以及纤溶标志物与慢性荨麻疹（CU）发病的关系并分析CU在发作期与缓解期不同状态下凝血状态、补体水平以及炎症标志物水平改变的情况。 方法 40例CU患者中缓解期CU 18例，发作期CU 22例，来自广州市血液中心的健康献血员40例作为健康对照组，用ELASA等方法检测凝血酶原片段F1+2（F1+2）、组织因子（TF）、血栓调节蛋白（TM）、高分子量激肽原（HMWK）、组织型纤溶酶原激活剂（t-PA）、C5a、C3、C4、血细胞沉降率（ESR）、抗溶血性链球菌O（ASO）、C反应蛋白（CRP）、类风湿因子（RF）水平，观察上述指标在CU发作期以及缓解期的改变。 结果 与健康对照组相比，CU患者血浆F1+2和HMWK水平明显升高（P < 0.01），而TF、TM和t-PA水平明显降低（P < 0.01）。CU患者的血浆F1+2、HMWK以及t-PA水平与症状评分相关（r = 0.81，P < 0.01；r = －0.39，P < 0.05；r = 0.35，P < 0.05）。CU患者发作期血浆F1+2水平较缓解期明显升高（P < 0.01）。TF、TM、HMWK、t-PA、C5a、C3、C4、ESR、ASO、RF、CRP水平在发作期与缓解期的差异均无统计学意义。 结论 凝血因子、抗凝因子以及纤溶标志物均参与CU发病。CU发作期与缓解期存在着F1+2水平的明显差异，提示凝血因子可能在CU发生发展中起作用。

关键词: 荨麻疹, 血液凝固, 补体系统蛋白质类, 炎症

Abstract: Liang Bihua, Li Runxiang, Lin Luyang, Li Zhenjie, Xiao Changqing, Zhu Huilan. Guangzhou Institute of Dermatology and Venereology, Guangzhou 510095, China Corresponding author: Zhu Huilan, Email: zhlhuilan@hotmail.com 【Abstract】　Objective To determine the coagulation status as well as circulating levels of complement and inflammation markers in patients with chronic urticaria （CU） during acute attack and in remission, and to estimate the relationship of coagulant and anticoagulant factors as well as fibrinolytic markers with the development of chronic urticaira. Methods This study included 40 patients with CU （22 during acute attack and 18 in remission） and 40 healthy blood donors from the Guangzhou Blood Center. Venous blood samples were obtained from these subjects, and enzyme-linked immunosorbent assay （ELISA） was performed to measure the plasma levels of prothrombin fragment 1+2 （F1+2）, tissue factor （TF）, thrombomodulin （TM）, high molecular weight kininogen （HMWK）, tissue-type plasminogen activator （t-PA）, C5a and serum levels of C3, C4, antistreptolysin O antibodies（ASO）, rheumatoid factor （RF） and C-reactive protein （CRP）. Erythrocyte sedimentation rate （ESR） was also determined in these patients. Comparisons of these parameters were carried out by using t test, and the correlation of these factors with CU was evaluated by using Spearman correlation coefficient. Results Compared with the healthy controls, the patients with CU showed significantly higher plasma levels of F1+2 and HMWK （both P < 0.01）, but lower levels of TF, TM and t-PA（all P < 0.01）. The plasma levels of F1+2, HMWK, t-PA were significantly correlated with the symptom scores in patients with CU （r = 0.81, P < 0.01; r = －0.39, P < 0.05; r = 0.35, P < 0.05）. A significant increase was observed in the plasma concentration of F1+2 in patients during acute attack compared with those in remission （P < 0.01）, whereas no significant differences were noted in the plasma levels of TF, TM, HMWK, t-PA, C5a, serum levels of C3, C4, ASO, RF and CRP or ESR between the two groups of patients （all P > 0.05）. Conclusions It seems that coagulation, anti-coagulation and fibrinolysis are all involved in the development of urticaria. There is an obvious difference in the plasma level of prothrombin F1+2 between patients with CU during acute attack and in remission, suggesting that coagulation factors play a certain role in the initiation and progression of CU.

Key words: Urticaria, Blood coagulation, Complement system proteins, Inflammation

引用本文

梁碧华 李润祥 林路洋 李振洁 肖常青 朱慧兰. 慢性荨麻疹发作期与缓解期凝血状态、补体以及炎症标志物水平的改变[J]. 中华皮肤科杂志, 2014,47(1):30-32. doi: