中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (2): 130-132.

• 研究报道 • 上一篇    下一篇

人乳头瘤病毒L1蛋白在尖锐湿疣组织中的表达

卜璋于1,郑伟2,吴黎明3,周虹1,俞小虹1   

  1. 1. 杭州市第一人民医院
    2. 浙江大学医学院附属第二医院妇产科
    3. 浙江省杭州市第一人民医院
  • 收稿日期:2012-03-05 修回日期:2012-09-20 出版日期:2013-02-15 发布日期:2013-02-01
  • 通讯作者: 俞小虹 E-mail:honghaijj@yahoo.cn
  • 基金资助:
    杭州市医药卫生科技计划项目

Expression of human papillomavirus L1 protein in lesions of condyloma acuminatum

  • Received:2012-03-05 Revised:2012-09-20 Online:2013-02-15 Published:2013-02-01

PDF

3

赞

摘要： 目的 探讨人乳头瘤病毒（HPV）L1蛋白在尖锐湿疣组织中的表达及临床意义。方法 用免疫组化法检测HPV L1蛋白在43例尖锐湿疣患者组织中的表达，并观察CO2激光治疗后的复发率和复发次数。 结果 43份尖锐湿疣标本中，HPV L1蛋白阳性率为83.72%（36/43）。在HPV6/11型、HPV6/11型合并HPV16/18型、HPV16/18型患者中L1蛋白表达阳性率依次降低，差异有统计学意义（?字2 = 17.90，P < 0.01）。随访12周，复发率为69.77%（30/43），平均复发次数为2.16次。HPV L1蛋白表达强阳性病例的复发率和复发次数依次低于中度阳性、弱阳性和阴性病例的复发率和复发次数，差异均具有统计学意义（χ2值分别为8.02，46.92，P值分别 < 0.05，0.01）。HPV L1蛋白表达程度越强与复发率和平均复发次数越低呈负相关，rs值分别为-0.429，-0.696，P值均 < 0.01。 结论 HPV L1蛋白有可能成为判断尖锐湿疣预后和复发的特异性临床生物指标之一。

关键词: 尖锐湿疣, 人乳头状瘤病毒, L1蛋白

Abstract: BU Zhang-yu*, ZHENG Wei, WU Li-ming, ZHOU Hong, YU Xiao-Hong. *Department of Dermatology, Hangzhou First People′s Hospital, Clinical Research Hospital of Zhejiang Academy of Medical Sciences, Hangzhou 310006, China Corresponding author: YU Xiao-hong, Email: honghaijj@yahoo.cn 【Abstract】 Objective To investigate the expression of human papillomavirus（HPV） L1 protein in lesional tissue of condyloma acuminatum and its clinical significance. Methods Forty-three patients with condyloma acuminatum were included in this study, and received CO2 laser therapy. Tissue samples were resected from the lesions of these patients at their first visit before treatment. Immunohistochemistry was used to determine the expression of HPV L1 protein in these samples. Follow up was carried out once every 2 weeks for 3 months to assess the recurrence rate and frequency in these patients after treatment. Results HPV L1 protein was detected in 83.72%（36/43） of these tissue samples. The expression rate of HPV L1 protein decreased sequentially from patients infected with HPV 6/11, patients with both HPV 6/11 and 16/18, to those with HPV16/18 （?字2 = 17.90, P < 0.01）. During the 12 weeks of follow up, the recurrence rate was 69.77% （30/43） with the average number of recurrence of 2.16. There was a sequential reduction in the recurrence rate and number from patients with strong expression of HPV L1 protein, to those with moderate expression, slight expression and negative expression （?字2 = 8.02, 46.92, P < 0.05 and 0.01, respectively）. The expression intensity of HPV L1 protein was negatively correlated with the recurrence rate and frequency （rs = －0.429, －0.696, respectively, both P < 0.01）. Conclusion HPV L1 protein may serve as a helpful molecular biomarker for the prediction of prognosis and recurrence of condyloma acuminatum.

Key words: Condyloma Acuminatum

中图分类号: 

  • R752.5+3