中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (2): 126-127.

• 研究报道 • 上一篇    下一篇

单卵双胎同患慢性光化性皮炎四代一家系调查

杨永茂1,贾梅1,沈敏娟2,杨桂兰3,郝春梅1,潘凤军1   

  1. 1. 内蒙古巴彦淖尔市医院
    2. 兰州甘肃省中医学院附属医院皮肤科
    3. 南方医科大学深圳医院
  • 收稿日期:2012-05-08 修回日期:2012-07-11 出版日期:2013-02-15 发布日期:2013-02-01
  • 通讯作者: 杨永茂 E-mail:Neilyangyongmao@126.com

Both monovular twins suffered from chronic actinic dermatitis: a survey in a four-generation family

  • Received:2012-05-08 Revised:2012-07-11 Online:2013-02-15 Published:2013-02-01

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摘要： 目的 探讨单卵双胎同患慢性光化性皮炎4代一家系发病情况及病变特征，明确其遗传关系。 方法 对先证者及其家族的临床资料、实验室检查进行分析。结果 家系4 代76 名成员中共检出慢性光化性皮炎患者22 例，其中男14例，女8 例，有关的实验室检查及环境因素调查均为阴性。结论 慢性光化性皮炎一家系调查中显示具有遗传性特性，符合常染色体显性遗传规律。

关键词: 光过敏疾患, 系谱

Abstract: YANG Yong-mao*, JIA Mei, SHEN Min-juan, YANG Gui-lan, HAO Chun-mei, PAN Feng-jun. *Bayannaoer Hospital, Bayannaoer 015000, Inner Mongolia, China 【Abstract】 Objective To investigate the clinical feature and prevalence of chronic actinic dermatitis in a four-generation family with both monovular twins affected by chronic actinic dermatitis. Methods The clinical and laboratory findings from monovular twins simultaneously affected by chronic actinic dermatitis and their four-family members were analyzed. Results There were 76 members in the four-generation family, with 22 members （including 14 males and 8 females） diagnosed with chronic actinic dermatitis. No positive results were found from laboratory examinations or environmental survey. Conclusion Chronic actinic dermatitis was inherited in an autosomal mode in this family.