中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (12): 899-901.

• 研究报道 • 上一篇    下一篇

广西壮族自治区性病门诊就诊的人类免疫缺陷病毒I型感染者丙型肝炎病毒感染的调查

王红春1,尹跃平2,魏万惠3,韩燕1,钟铭英4,朱邦勇5,陈祥生2   

  1. 1. 中国医学科学院皮肤病研究所
    2. 南京 中国医学科学院北京协和医学院皮肤病研究所
    3. 中国医学科学院北京协和医学院皮肤病研究所
    4. 中国医学科学院皮肤病医院
    5. 广西皮肤病防治研究所
  • 收稿日期:2011-11-29 修回日期:2012-07-17 出版日期:2012-12-15 发布日期:2012-11-30
  • 通讯作者: 尹跃平 E-mail:yinyp@ncstdlc.org

Hepatitis C virus infection among sexually transmitted disease clinic attendees infected with human immunodeficiency virus type 1: a survey in Guangxi Zhuang Autonomous Region

  • Received:2011-11-29 Revised:2012-07-17 Online:2012-12-15 Published:2012-11-30

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摘要：

目的 了解广西壮族自治区性病门诊就诊的人类免疫缺陷病毒I型（HIV-1）感染者中丙型肝炎病毒（HCV）感染情况。方法 对11 553份性病门诊就诊者血浆标本进行HIV抗体筛查、确证，并采用病例对照研究方法，按年龄、婚姻状况和1 ∶ 2的比例，140份HIV-1抗体确证阳性标本配对282份HIV-1抗体阴性标本。422份标本采用酶联免疫吸附试验（ELISA）进行HCV抗体检测。利用卡方检验对HIV-1抗体阳性者及HIV-1抗体阴性者HCV抗体阳性率进行比较，采用Logistic回归对HCV和HIV合并感染进行危险性分析。 结果 HIV-1抗体阳性标本HCV抗体阳性率为33.57%（47/140），HIV-1抗体阴性标本为1.06%（3/282），后者显著低于前者（χ2 = 94.66，P < 0.05）。危险因素分析显示，多个性伴合并感染HCV和HIV的概率高于单个性伴〔OR = 2.4，95%CI （1.0 ~ 5.6），P = 0.05〕，静脉吸毒者合并感染HCV和HIV的概率高于非静脉吸毒者〔OR = 20.8，95% CI （5.7 ~ 76.5），P < 0.05〕。结论 HCV感染与HIV感染相关，对HIV-1就诊者进行综合干预能降低HCV的传播。

关键词: 数据收集

Abstract:

Objective To estimate the prevalence of hepatitis C virus （HCV） infection among sexually transmitted disease （STD） clinic attendees infected with human immunodeficiency virus type 1 （HIV-1） in Guangxi Zhuang Autonomous Region. Methods Totally, 11 553 blood plasma samples were collected from STD clinic attendees in Guangxi Zhuang Autonomous Region, and subjected to HIV-1 antibody screening and confirmatory testing. Enzyme linked immunosorbent assay （ELISA） was performed to detect anti-HCV antibodies in 140 anti-HIV-1 antibody-positive samples and 282 anti-HIV-1 antibody-negative samples from age- and marital status-matched attendees. Chi-square test was performed to assess the differences in the prevalence rate of HCV infection between anti-HIV-1-negative and -positive samples, and Logistic regression analysis to evaluate the risk factors for HCV and HIV co-infection. Results The positivity rate of anti-HCV antibodies was 33.57% （47/140） among anti-HIV-1-positive samples, significantly higher than that in anti-HIV-1-negative samples （1.06% （3/282), χ2 = 94.66, P < 0.05）. Logistic regression analysis showed a statistical increase in the prevalence of HCV/HIV co-infection in individuals reporting more than one sexual partners compared with those reporting only one sexual partner （OR = 2.4, 95% CI （1.0－5.6）, P = 0.05） , and in intravenous drug users compared with non-intravenous drug users （OR = 20.8, 95% CI（5.7－76.5）, P < 0.05）. Conclusions HCV infection appears to be associated with HIV-1 infection, and comprehensive intervention on HIV-1-infected patients may slow down HCV transmission.