中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (7): 517-518.

• 研究报道 • 上一篇    下一篇

Spa-1和Ki-67在乳房外Paget病肿瘤组织中的表达

张琛1,钱悦2,冯爱平3,陈思远4,吴艳5,高炳爱5,刘岩5,徐钧5   

  1. 1. 北京航天总医院
    2. 武汉协和医院皮肤科
    3. 武汉市协和医院皮肤科
    4. 武汉市华中科技大学同济医学院附属协和医院皮肤科
    5.
  • 收稿日期:2010-09-19 修回日期:2010-11-26 出版日期:2011-07-15 发布日期:2011-07-12
  • 通讯作者: 钱悦 E-mail:qianyue0111@sohu.com
  • 基金资助:

    国家自然科学基金

Expression of Spa-1 and Ki-67 in tissues of extramammary Paget′s disease (EMPD)

  • Received:2010-09-19 Revised:2010-11-26 Online:2011-07-15 Published:2011-07-12

摘要:

目的 探讨Spa-1在乳房外Paget病发生和转移中可能的作用。方法 取17例原位乳房外Paget病和12例侵袭性乳房外Paget病患者皮损及9例正常人皮肤组织,用免疫组化分别检测Spa-1和Ki-67的表达。结果 Spa-1在胞质中显色,Ki-67在胞核中显色。Spa-1和Ki-67仅少量表达于正常人皮肤基底层,在乳房外Paget病肿瘤组织中的表达明显高于正常人皮肤(P < 0.01)。Spa-1在侵袭性乳房外Paget病肿瘤组织中表达明显高于原位乳房外Paget病(P < 0.01)。乳房外Paget病肿瘤组织中Spa-1的表达与Ki-67的表达呈正相关。结论 Spa-1在乳房外Paget病的发生发展中可能起作用。

关键词: Ki-67

Abstract:

Objective To investigate the potential role of Spa-1 in the development and metastasis of EMPD. Methods Tissue specimens were resected from 17 patients with primary EMPD, 12 patients with invasive EMPD and 9 normal human controls. Immunohistochemistry was performed to measure the expression of Spa-1 and Ki-67. Results Positive staining was observed for Spa-1 in cytoplasm, and for Ki-67 in cell nuclei. Spa-1 and Ki-67 were weakly expressed in the basal layer of normal skin. The expression of Spa-1 and Ki-67 in EMPD tissue were statistically higher than those in the normal control tissue(both P < 0.01). Increased expression of Spa-1 was noted in invasive EMPD tissue compared with in situ EMPD tissue. The expression of Spa-1 was positively correlated with that of Ki-67 in the tissue of EMPD. Conclusion Spa-1 may play a certain role in the initiation and progression of EMPD.

Key words: Ki-67