过氧化物酶体增殖物激活受体在寻常性银屑病患者表皮中的表达

中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (7): 519-521.

过氧化物酶体增殖物激活受体在寻常性银屑病患者表皮中的表达

庞晓文¹,杨雪琴²,张萍³,朱赛楠⁴

1. 解放军空军总医院皮肤科
2. 北京空军总医院皮肤科
3. 空军总医院
4.

收稿日期:2010-09-09 修回日期:2011-03-27 出版日期:2011-07-15 发布日期:2011-07-12
通讯作者: 庞晓文 E-mail:pangxiaowen6712@163.com

Expression of peroxisome proliferator-activated receptors in the epidermis of skin from patients with psoriasis vulgaris

Received:2010-09-09 Revised:2011-03-27 Online:2011-07-15 Published:2011-07-12

摘要/Abstract

摘要：

目的研究过氧化物酶体增殖物激活受体（PPAR）在寻常性银屑病患者表皮角质形成细胞中的表达和意义。方法采用免疫组化方法检测PPARα、β/δ、γ在5例正常人表皮、17例寻常性银屑病患者皮损及非皮损表皮中的表达，并用图像分析方法进行半定量分析。结果 PPARα、β/δ、γ在正常人表皮角质形成细胞中均有不同程度的细胞核表达；在银屑病皮损表皮中的表达强度均较非皮损处下降（P ＜ 0.01）。在银屑病非皮损表皮中，PPARβ/δ、γ的表达强度均较正常人表皮明显升高（P ＜ 0.01）。结论 PPARα表达下调可能参与了银屑病表皮角质形成细胞过度增生和分化不全的病理过程，而PPARβ/δ、γ在维持表皮细胞正常增生分化稳态中可能发挥协同作用。

关键词: 过氧化物酶体增殖物激活受体

Abstract:

Objective To investigate the expression of peroxisome proliferator-activated receptors （PPARs） in epidermal keratinocytes of patients with psoriasis vulgaris and its significance. Methods Immunohistochemical method was used to examine the expression of PPARα, β/δ and γ in tissue specimens from the normal skin of 5 human controls, lesional and normal skin adjacent to the lesions of 17 patients with psoriasis vulgaris. A semi-quantitative analysis was carried out by image analyzer. Results Different levels of expression of the three PPAR isotypes were observed in the nuclei of epidermal keratinocytes of normal human controls. The expression intensity of PPAR α, β/δ and γ was statistically higher in the epidermis of adjacent normal skin than that in psoriatic lesions （all P < 0.01） and normal control skin （all P < 0.01）. Conclusions The decreased expression of PPARα may be associated with the overproliferation and parakeratosis of epidermal keratinocytes in psoriatic lesions, and PPAR β/δ and γ may display a synergistic effect on the maintenance of homeostatic proliferation and differentiation of epidermal cells.

Key words: peroxisome proliferators activated receptor

庞晓文杨雪琴张萍朱赛楠. 过氧化物酶体增殖物激活受体在寻常性银屑病患者表皮中的表达[J]. 中华皮肤科杂志, 2011, 44(7): 519-521.

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