银屑病性关节炎患者血清中转化生长因子-β1的检测

中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (7): 513-514.

银屑病性关节炎患者血清中转化生长因子-β1的检测

杨雁¹,杨静²,段西凌³,李薇⁴

1. 四川省人民医院皮肤性病研究所
2.
3. 四川省医学科学院四川省人民医院皮肤科
4. 四川大学华西医院皮肤科

收稿日期:2010-09-15 修回日期:2010-11-16 出版日期:2011-07-15 发布日期:2011-07-12
通讯作者: 杨雁 E-mail:wanxisha@163.com
基金资助:
四川省卫生厅科研基金

Measurement of transforming growth factor （TGF）-β1 in sera of patients with psoriatic arthritis

Received:2010-09-15 Revised:2010-11-16 Online:2011-07-15 Published:2011-07-12

摘要/Abstract

摘要：

目的探讨银屑病性关节炎患者血清中转化生长因子（TGF）-β1的表达及其意义。方法分别检测银屑病性关节炎患者与寻常性银屑病患者血清中TGF-β1的水平。结果 38例银屑病性关节炎患者血清中的TGF-β1浓度为375.92 ± 95.88 pg/ml，80例寻常性银屑病患者为510.78 ± 167.97 pg/ml，两组差异有统计学意义（t = 4.60，P < 0.01）。结论对银屑病性关节炎患者进行血清TGF-β1浓度的动态监测，有助于引起临床医师对银屑病性关节炎骨质疏松的警惕和预防。

关键词: 骨质疏松

Abstract:

Objective To measure the expression of TGF-β1 in the sera of patients with psoriatic arthritis and its significance. Methods The serum level of TGF-β1 was measured in 38 patients with psoriatic arthritis and 80 patients with psoriasis vulgaris. Results A significant difference was observed between the patients with psoriatic arthritis and those with psoriasis vulgaris （375.92 ± 95.883 pg/ml vs. 510.78 ± 167.967 pg/ml, t = 4.60, P < 0.01）. Conclusion Continuous monitoring of serum levels of TGF-β1 may help clinicians to take precautions against osteoporosis in patients with psoriatic arthritis.

Key words: osteoporosis

杨雁杨静段西凌李薇. 银屑病性关节炎患者血清中转化生长因子-β1的检测[J]. 中华皮肤科杂志, 2011, 44(7): 513-514.

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