中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (11): 765-767.

• 论著 • 上一篇    下一篇

常规剂量氯雷他定对皮肤斑贴试验反应程度的影响

黎平1,孙晓东2,3,施辛4,蔡永莲4,张静4,陈小建4,陈玲玲4,5,谢立夏2   

  1. 1. 四川省903医院
    2. 苏州大学附属第二医院皮肤科
    3. 唐山市丰南区妇幼医院
    4. 苏州大学附属第二医院
    5. 苏州市立医院本部
  • 收稿日期:2011-01-24 修回日期:2011-03-15 出版日期:2011-11-15 发布日期:2011-11-01
  • 通讯作者: 施辛 E-mail:shx9@163.com

Influences of routine-dose loratadine on the intensity of patch test reaction

Ping Li1,Xiao-Dong SUN1,2, Yonglian Cai1,Jing Zhang1,xiao-jian CHEN4,lingling CHEN1,1,Li-Xia XIE1   

  • Received:2011-01-24 Revised:2011-03-15 Online:2011-11-15 Published:2011-11-01

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摘要：

目的 探讨常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验的影响。方法 采用随机、双盲、对照方法，121例斑贴试验硫酸镍阳性的患者分为两组，试验组61例口服氯雷他定片10 mg，每日1次，连续14 d；对照组60例口服安慰剂1片，每日1次，连续14 d。在服药第11天进行斑贴试验，在服药第14天判读斑贴试验结果。结果 试验组有55例、对照组有53例患者斑贴试验反应程度没有改变，两组结果差异无统计学意义。结论 常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验反应程度没有抑制作用。

关键词: 抑制作用

Abstract:

Objective To investigate the influences of routine-dose loratadine on the positive patch test reaction to nickel sulfate. Methods A double-blind, controlled and randomized study was carried out. A total of 121 patients with a positive patch test reaction to nickel sulfate were divided into two groups to receive loratadine 10 mg （experimental group, n = 61） or placebo （control group, n = 60） once daily for 14 days. The patch testing of nickel sulfate was performed on day 11, and clinical evaluation of the test was carried out on day 14 after the start of treatment. The intention to treat population was used for data analysis. Results No changes were observed in the intensity of patch test reaction to nickel sulfate in 55 patients in the experimental group or 53 patients in the control group, and there was no significant difference between the two groups in the percentage of patients showing changes in the intensity of patch test reaction （9.8% vs. 11.7%, χ2 = 0.11, P > 0.05）. Conclusion The routine-dose loratadine has no inhibitory effect on the intensity of skin patch test reaction to nickel sulfate.

Key words: inhibitory effect