中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (1): 62-63.

• 药物与临床 • 上一篇    下一篇

盐酸依匹斯汀每日/隔日疗法治疗慢性荨麻疹临床观察

张江安1,于建斌2,王宏瑾3,李红文4   

  1. 1. 郑州大学第一附属医院
    2. 郑州大学第一附属医院皮肤科
    3. 郑州大学护理学院临床教研室
    4. 郑州大学附属第一医院皮肤科
  • 收稿日期:2010-06-17 修回日期:2010-06-23 出版日期:2011-01-15 发布日期:2011-01-10
  • 通讯作者: 于建斌 E-mail:yjbdoctor@sina.com

Daily and alternate-day regimen of epinastine hydrochloride in the treatment of chronic urticaria: a clinical observation

  • Received:2010-06-17 Revised:2010-06-23 Online:2011-01-15 Published:2011-01-10

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摘要：

[摘要] 目的 观察盐酸依匹斯汀每日-隔日疗法治疗慢性荨麻疹的疗效和安全性。方法 80例患者被随机分为试验组和对照组，各40例。前者先服盐酸依匹斯汀片10mg，1次/d，连续4周，后改为10mg，隔日1次，再服4周；后者口服盐酸依匹斯汀片10mg，1次/d，连续8周。结果 试验组的有效率、不良反应发生率分别为82.05%、7.69%，对照组依次为89.47%、5.26%，两组有效率、不良反应发生率比较均无统计学意义(Ｐ均>0.05)。试验组的成本-效果比低于对照组，且服药次数明显减少。结论 盐酸依匹斯汀每日-隔日疗法治疗慢性荨麻疹疗效好、安全、经济且方便。

关键词: 荨麻疹

Abstract:

[Abstract] Objective To observe the efficacy and safety of daily-intermittent epinastine therapy in the treatment of chronic urticaria. Methods A randomized, parallel comparative clinical observation was performed in 80 patients with chronic urticaria. They were divided into two groups, experimental group and control group. The experimental group was treated with daily-intermittent epinastine therapy (In the first four weeks, the patients in this group were given the drug 10mg every day; in the following 4 weeks, given the drug 10mg every other day. )，and the control group with daily epinastine therapy(The patients in this group were given the drug 10mg every day for 8 weeks). Results The total effective rate of the experimental group was 82.05% and 89.47% in the control group. The side effect rate of the experimental group was 7.69% and 5.26% in the control group. There was no significant difference between the two groups’ total effective rate, as well as those side effect rate (Ｐall>0.05). Cost-effectiveness ratio of the experimental group was lower than that in the control group, and times of taking drugs of the experimental group less than that in the control group. Conclusions It is effective, safety, economical and convenient for daily-intermittent epinastine therapy in the treatment of chronic urticaria.

Key words: Urticaria