中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (9): 604-606.

• 论著 • 上一篇    下一篇

山东汉族关节病性银屑病与HLA-A、B等位基因相关性研究

屈丽娜1,张福仁2,杨宝琦1,朱传福3,田洪青4   

  1. 1. 山东省皮肤病性病防治研究所
    2. 济南山东省皮肤病防治研究所 250022
    3.
    4. 济南市山东省皮肤病性病防治研究所
  • 收稿日期:2008-09-10 修回日期:2009-03-19 出版日期:2009-09-15 发布日期:2012-03-21
  • 通讯作者: 屈丽娜 E-mail:leina988@yahoo.com.cn
  • 基金资助:
    2007GG10002016;省级基金（编号）

Relationship between human leukocyte antigen-A, -B alleles and psoriatic arthritis in Chinese Han population from Shandong Province

  • Received:2008-09-10 Revised:2009-03-19 Online:2009-09-15 Published:2012-03-21

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摘要： 目的 探讨HLA-A、B等位基因与山东汉族关节病性银屑病及其临床特征的相关性。方法 PCR-寡核苷酸探针杂交分型法（PCR-SSOP）对42例山东汉族关节病性银屑病患者（患者组）与90例健康献血者（对照组）进行HLA-A、B等位基因分型。结果 两组比较，关节病性银屑病患者组B*27等位基因频率（患者组为11%，对照组为1.8%，Pc < 0.01）、B*57等位基因（分别为4.8%和0.4%，Pc < 0.05）及B*13/B*27杂合体（分别为8.5%和0.5%，Pc < 0.01）的出现频率明显高于对照组，A*33等位基因频率（分别为0.6%和6.7%，Pc < 0.01）明显低于对照组。B*27等位基因频率在关节病性银屑病脊柱受累组为80%，无脊柱受累组为 22%（两组比较，P < 0.01）；外周附着点受累组为63%，无外周附着点受累组为23%（P < 0.05）。7例B*13/27杂合体阳性者中5例（71%）有脊柱炎合并外周关节炎，而36例B*13/27杂合体阴性者中有8例（22%），两组比较，χ2 = 6.73，P < 0.05。结论 HLA-B*27与山东汉族关节病性银屑病相关。

关键词: 关节炎，牛皮癣, 等位基因, HLA抗原

Abstract: Objective To investigate the relationship of human leukocyte antigen （HLA）-A, B alleles to psoriatic arthritis （PsA） and its clinical subtypes in Chinese Han population from Shandong Province. Methods Polymerase chain reaction-sequence specific oligonucleotide probe （PCR-SSOP） method was used to determine HLA-A, B alleles in 42 consecutive PsA patients and 90 healthy human controls of Han Nationality from Shandong Province. Results A significant increase was observed in the frequencies of HLA-B*27 （11% vs 1.8%, P < 0.01）, B*57（4.8% vs 0.4%, P < 0.01） alleles and B*13/B*27 heterozygote （8.5% vs 0.5%, P < 0.01） in PsA patients than those in the healthy controls, together with a decreased frequency of A*33 allele（0.6% vs 6.7%, P < 0.001）. In PsA patients, there was a significant difference in the frequency of B*27 allele between patients with spine involvement and those without （80% vs 22%, P < 0.01）, as well as between those with peripheral enthesis involvement and those without （63% vs 23%, P < 0.05）. Spondylitis incorporating peripheral arthritis was noted in 5 out of 7 patients positive for HLA B*13/B*27 heterozygote, compared to 8 out of 36 negative for HLA B*13/B*27 heterozygote （χ2 = 6.73, P < 0.05）. Conclusion The HLA-B*27 allele is correlated with PsA in Chinese Han population from Shandong Province.