中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (5): 311-314.

• 论著 • 上一篇    下一篇

女性淋球菌感染症状的某些相关因素分析

吴志洪1,陈宏翔1,陈嵘祎2,涂亚庭3   

  1. 1. 华中科技大学同济医学院附属协和医院
    2. 广东省湛江市广东医学院附属医院
    3. 武汉华中科技大学同济医学院附属协和医院皮肤科
  • 收稿日期:2008-06-10 修回日期:2009-01-13 出版日期:2009-05-15 发布日期:2009-05-13
  • 通讯作者: 吴志洪
  • 基金资助:

    国家自然科学基金课题（No.30700717、No.30371293；国家高校博士点基金（20070487140);国家高校博士点基金资助（编号）

Some factors correlated with the symptoms of female gonococcal infections

  • Received:2008-06-10 Revised:2009-01-13 Online:2009-05-15 Published:2009-05-13

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摘要：

目的 探讨女性淋球菌感染症状与衣原体感染及体内性激素水平等因素之间的关系。方法结合我国宫颈炎诊断标准并参考国外文献，选择136例无明显症状淋病患者为观察组，45例有症状者为对照组，检测宫颈分泌物衣原体及淋球菌DNA； 放射免疫法测定雌二醇和孕酮浓度；用RT-PCR和ELISA的方法在mRNA水平和蛋白水平检测炎症因子TNF-α、IL-1β的表达。用SPSS 12.0软件进行统计学分析。结果 淋病的无明显症状感染与衣原体感染无显著相关性（χ2 = 0.016，P ＞ 0.05），但其炎症因子TNF-α、IL-1β减少与血清孕激素水平升高的相关性具有统计学意义（r = -0.8798，P < 0.01；r = -0.8935，P < 0.01）。结论 女性感染淋病时体内的高水平孕激素可能是导致其无明显症状的原因之一。

关键词: 淋球菌；无症状感染；孕激素

Abstract:

Objective To study the relationship of symptoms of female gonococcal infections to Chlamydia trachomatis infection, serum sex hormone levels, etc. Methods A total of 136 gonorrhea female patients without obvious symptoms were recruited in this study together with 45 gonorrhea patients with obvious symptoms as the controls. Serum progesterone （P） and estradiol （E2） levels were measured by radio immunoassay （RIA）. Cervical swabs were obtained from the subjects and eluted into isotonic saline solution, the elution was divided into 2 portions and tested for the levels of TNF-α and IL-1β by ELISA and for the DNA of C. trachomatis and N. gonorrhea with PCR. Statistical analysis was carried out by SPSS for Windows （version 12.0）. Results There was no statistical correlation between C. trachomatis infection and asymptomatic status of female gonococcal infection （χ2 = 0.016, P > 0.05）. However, the decrease in the level of TNF-α and IL-1β significantly correlated with the increase in serum progestogen （r = -0.8798, -0.8935, respectively, both P < 0.01）. Conclusion The high serum level of progesterone may be associated with the asymptomatic status of gonococcal infection.