中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (4): 285-286.

• 药物与临床 • 上一篇    下一篇

依匹斯汀与左西替利嗪治疗慢性荨麻疹多中心随机双盲对照研究

闫毅,曾海   

  1. 江西省赣州市皮肤病医院
  • 收稿日期:2008-05-04 修回日期:2008-05-27 出版日期:2009-04-15 发布日期:2009-04-14
  • 通讯作者: 闫毅
  • 基金资助:

    无

A multicenter, randomized, double-blind, controlled study on the efficacy of epinastine vs levocetirizine in chronic urticaria

  • Received:2008-05-04 Revised:2008-05-27 Online:2009-04-15 Published:2009-04-14

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摘要：

目的：研究和比较依匹斯汀和左西替利嗪治疗慢性荨麻疹的疗效和安全性。方法：选择慢性荨麻疹患者为研究对象，采用多中心、随机、双盲、双模拟和对照临床研究。试验组依匹斯汀胶囊每日1次，每次10mg，对照组盐酸左西替利嗪胶囊每日1次，每次5mg，均连续服用28天。于用药后随访，观察疗效和不良反应。结果：入选病例131例，可评价疗效和安全性病例120例。经28天治疗后依匹斯汀组及左西替利嗪组总有效率分别为70.05％、67.79％，两组比较差异无显著性（P=0.2564）。依匹斯汀组和左西替利嗪组不良反应发生率分别为11.48％和23.33％。结论：依匹斯汀治疗慢性荨麻疹安全有效。

Abstract:

objective: To investigate and compare the effect and safety of epinastine and levocetirizine for the treatment of chronic urticaria (CU)．Methods: A randomized, double-blind, double-dummy, multicenter, parallel control clinical trial was employed．The patients with CU were divided into epinastine group and levocetirizine group．Epinastine (10mg／day)or levocetirizine (5mg／day) were taken once daily for 28 days，and were followed up on the 28th day after starting treatment. Results: One hundred and twenty cases were evaluable for the effect and safety at the end of the study． The effective rates in epinastine group and in levocetirizine group were 70.05% and 67.79%.There was no significant difference between the two groups（P=0.2564）． The drug adverse reaction for epinastine group and levocetirizine group were 11.48% and 23.33% respectively. Conclusion: Epinastine is an efficient and safe antihistaminic drug on treating chronic urticaria.

Key words: Epinastine; levocetirizine; Urticaria; randomized controlled trials; double-blind method