中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (2): 143-143.

• 短篇论著 • 上一篇    下一篇

内皮素-1、内皮素转化酶-1和 肿瘤坏死因子-α在脂溢性角化病皮损中的表达

吴娟 盛晚香   

  1. 武汉大学中南医院 武汉大学中南大学皮肤科
  • 收稿日期:2008-02-26 修回日期:2008-03-25 出版日期:2009-02-15 发布日期:2009-02-15
  • 通讯作者: 吴娟 E-mail:wj_whu@126.com

Expression of endothelin-1, endothelin converting enzyme and tumor necrosis factor-α in seborrheic keratosis

WU Juan   

  • Received:2008-02-26 Revised:2008-03-25 Online:2009-02-15 Published:2009-02-15
  • Contact: WU Juan E-mail:wj_whu@126.com

PDF (PC)

226

赞

摘要：

目的: 探讨内皮素-1（ET-1）、内皮素转换酶-1( ECE-1)和肿瘤坏死因子-α（TNF-α）在脂溢性角化病(seborrheic keratosis , SK) 皮损出现色素沉着的发病机制。方法: 采用免疫组化SP 法检测30 例脂溢性角化病(SK) 皮损组织中ET-1、ECE-1和 TNF-α的表达,并选用10 例正常皮肤组织作为对照。结果:SK组中ET-1、ECE-1和 TNF-α的阳性表达程度分别显著高于对照组。结论: SK组织中存在ET-1、ECE-1和 TNF-α的过度表达,这种异常高表达的ECE-1和 TNF-α可能通过参与脂溢性角化病(SK)的自分泌生长环路而上调ET-1的表达，并且与脂溢性角化病(SK)的色素沉着有关。

Abstract:

Objective: To investigate the expression of ET-1、ECE-1 and TNF-α in pathogenesis of seborrheic keratosis (SK) . Methods: The ET-1、ECE-1 and TNF-α expression in sit u in 30 cases of SK and 10 cases of normal skin tissue were examined by immunohisto-chemistry assay. Results : The expressive intensity of ET-1、ECE-1 and TNF-αin the SK group was significantly higher than that in the controls. Conclusions: These findings suggest that the increased secretion of ET-1 leading to enhanced pigmentation in SK results from the co-ordinated increased expression of TNF-α and ECE-1.