中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (12): 864-865.

• 临床经验 • 上一篇    下一篇

阿维A治疗四例基底细胞上皮瘤临床观察

张锡宝1,黄振明2,张三泉1,罗育武3,何玉清1,林玲1   

  1. 1. 广州市皮肤病防治所
    2. 广州市皮肤病防治所皮肤科
    3. 广东省广州市皮肤病防治所皮肤科
  • 收稿日期:2009-01-22 修回日期:2009-10-08 出版日期:2009-12-15 发布日期:2012-03-27
  • 通讯作者: 张锡宝 E-mail:zxibao@126.com

Clinical efficacy of tretinoin in basal cell carcinoma: a report of four cases

  • Received:2009-01-22 Revised:2009-10-08 Online:2009-12-15 Published:2012-03-27

PDF (PC)

121

赞

摘要：

我们采用口服阿维A及外用0.1％的维A酸霜成功治疗4例组织病理学证实为基底细胞癌患者。治疗结束时原位组织活检，原皮损部位组织细胞形态基本正常。治疗结束后每4周随访1次，观察肿瘤是否复发。4例患者随访6个月至4年不等，均未复发。在治疗及随访期间，实验室监测血常规、肝肾功能、血脂均正常。未见明显不良反应。我们认为口服阿维A可作为老年面部基底细胞癌患者的一种新的治疗方法。

关键词: 阿维A

Abstract:

We report here is about four cases with BCCs confirmed by histopatho- logy, whom have been treated by systemic acitretin and topical 0.1% retinoc acid cream. The four cases with BCCs showed good response to acitretin therapy. The patients were continued to be follows up every 4 weeks for clinical response and side effects occurred. The final follow-up for the 4 cases were 6 months to 4 years after the tumour was completely cleared. During treatment and follow-up, laboratory results remained within normal limits and examined by histopathology after the final follow up. These cases showed that the clinical signs and symptoms were completely cleared and no severe adverse effects were reported during the time on treatment and follow up, highlighting the therapeutic potential of oral acitretin in treatment of BCCs. The investigation was indicated that acitretin might be considered as a novel method of therapy for facial BCCs in aged person.