中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (12): 854-855.

• 短篇论著 • 上一篇    下一篇

过氧化物酶体增殖物激活受体-γ mRNA在寻常性银屑病患者皮损中的表达

朱小红1,李明2,金城3,杨莉佳4,蒋屏东4   

  1. 1. 无锡市第二人民医院
    2. 无锡市南京医科大学附属无锡第二医院皮肤科
    3. 南京医科大学附属无锡第二医院皮肤科
    4. 无锡市第二人民医院皮肤科
  • 收稿日期:2008-12-18 修回日期:2009-02-14 出版日期:2009-12-15 发布日期:2012-03-27
  • 通讯作者: 朱小红 E-mail:zxh6801@126.com

mRNA expressions of peroxisome proliferator-activated receptor-gamma in lesions of patients with psoriasis vulgaris

  • Received:2008-12-18 Revised:2009-02-14 Online:2009-12-15 Published:2012-03-27

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摘要：

【摘要】 目的 从mRNA水平研究过氧化物酶体增殖物激活受体γ（PPAR-γ）在寻常型银屑病患者皮损及非皮损皮肤中的表达，探讨其在银屑病发病中的作用。方法 采用RT-PCR对28例寻常型银屑病患者皮损及非皮损皮肤中PPAR-?mRNA的表达情况进行检测，同时以30例正常人皮肤作为对照。 结果 银屑病皮损中PPAR-γ mRNA的表达显著低于非皮损处皮肤(P<0.001)和正常人皮肤(P<0.001)；而且在皮损组内，进行期患者皮损处PPAR-γ mRNA的表达比静止期患者皮损处表达显著降低(P<0.01)，但非皮损皮肤的表达与正常人皮肤相比差异无显著性(P>0.05)。结论 寻常型银屑病患者皮损处PPAR-γmRNA表达显著降低，进行期患者皮损处PPAR-γmRNA的表达比静止期患者皮损处表达更低，提示PPAR-γ在银屑病的发病中可能起一定作用。

关键词: 过氧化物酶体类

Abstract:

【Abstract】 Objective To investigate the expression of peroxisome proliferator-activated receptor gama(PPAR-γ) in lesional and nonlesional skin in psoriasis at mRNA levels, and elucidate its roles in psoriasis vulgaris(PV). Methods The expression of PPAR-γmRNA was detected by RT-PCR in lesional and nonlesional skin in 28 psoriatic patients and 30 normals as control. Results Expressions of mRNA of PPAR-γ were detectable in most skin biopsies. Compared with normal skin and nonlesional skin, PPAR-γ mRNA was significantly decreased in psoriatic lesions (P<0.001). Furthermore, the expressions of PPAR-γ mRNA was decreased in lesional skin from psoriatic patients with active phase comparing with stationary phase (P<0.01). However, there was no significant difference of PPAR-γ mRNA expression between nonlesional skin and normal skin(P>0.05). Conclusion PPAR-γmRNA is lower expressed in psoriastic lesions, and PPAR-γ may plays an important role in occurrence of PV.