中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (12): 853-854.

• 短篇论著 • 上一篇    下一篇

云南汉族多形性日光疹与HLA-DQB1、DPB1等位基因相关性研究

苏顺琴1,孙素姣2,农祥3,杨智2,董天祥2,赵维佳2,肖春杰2,何黎4   

  1. 1. 云南省临沧市人民医院
    2. 昆明医学院第一附属医院皮肤科
    3. 昆明医学院第一附属医院
    4. 昆明市昆明医学院第一附属医院皮肤科
  • 收稿日期:2008-12-24 修回日期:2009-01-18 出版日期:2009-12-15 发布日期:2012-03-27
  • 通讯作者: 苏顺琴 E-mail:ssq2006177@yahoo.com.cn

Correlation of polymorphic sun light eruption with HLA-DQB1 and -DPB1 genes in Han Nationality from Yunnan Province

  • Received:2008-12-24 Revised:2009-01-18 Online:2009-12-15 Published:2012-03-27

摘要:

[摘要] 目的 探讨多形性日光疹(PLE)的发生与HLA-DQB1、DPB1等位基因的关系。方法:应用聚合酶链反应-直接测序法(PCR-SBT)的方法对38例PLE患者和45例健康人进行HLA-DQB1、DPB1等位基因的检测。结果:共检测出11种HLA-DQB1及9种DPB1等位基因,实验组中分别检出9种DQB1及8种DPB1等位基因,对照组分别检出11种DQB1和9种DPB1。其中DQB1*050301等位基因与PLE呈正相关(χ2=5.691,P<0.05),实验组DPB1*0501频率较对照组升高,但差异无统计学意义。结论:HLA-DQB1*050301可能是云南汉族PLE的易感等位基因,未发现HLA-DPB1可能的易感或保护基因。

关键词: DPB1

Abstract:

[Abstract] objective To explore the relationship between the allele of HLA-DQB1、DPB1 and polymorphous light eruption of the Han Nationality in Yunnan .Method HLA-DQB1、DPB1 tying of 38patients with PLE were investigated by PCR-SBT method, and the frequencies of HLA-DQB1.DPB1 alleles were compared. Result eleven kinds of HLA-DQB1and 9 kinds of DPB1 were found from the specimens, including 9 kinds of HLA-DQB1 and 8 kinds DPB1 of in PLE specimens, and eleven kinds of HLA-DQB1and 9 kinds of DPB1 in control specimens. Among them HLA-DQB1*05031 allele was positively associated with PLE(χ2=5.691,P<0.05),the frequencies of HLA-DPB1*0501 was higher than control,but the P was less than 0.05.Conclusion HLA-DQB1*05031 may be the susceptible allele of Yunnan Han nationality PLE patients ,no susceptible or protective allele.