中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (11): 739-741.

• 论著 • 上一篇    下一篇

上海地区女性外阴尖锐湿疣患者宫颈HPV感染及分型研究

王秀丽1,王宏伟1,杨连娟2   

  1. 1. 上海市皮肤病性病医院
    2. 上海市皮肤病性病医院性病研究室
  • 收稿日期:2008-12-01 修回日期:2009-02-25 出版日期:2009-11-15 发布日期:2009-11-13
  • 通讯作者: 王秀丽 E-mail:xlwang2001@yahoo.cn
  • 基金资助:

    中人厅发（2007）107号文;国家人事部回国人员启动基金（编号）

Relationship between Vulvar Condylomata Acuminata Lesion and Cervical HPV Infection in Patients of Shanghai Area

  • Received:2008-12-01 Revised:2009-02-25 Online:2009-11-15 Published:2009-11-13

PDF (PC)

153

赞

摘要：

[摘要] 目的 探讨上海地区女性外阴尖锐湿疣患者的宫颈HPV感染情况。方法 采用美国FDA批准的捕获杂交试验和基因芯片技术对194例女性外阴尖锐湿疣患者皮损和宫颈脱落细胞进行HPV 基因型别研究。结果 194例患者的女性外阴皮损HPV检出率为100%，其中低危型HPV为74.2%（144/194），高危型HPV为25.8%（50/194）；低危型以单一型别感染为主, 占94.4%（136/144），均为HPV6或HPV11。 高危型以混合型别感染为主，86%（43/50）患者为低危与高危型HPV混合感染。194例患者的宫颈脱落细胞中，除了14.4%（28/194）的患者未合并HPV感染外，有85.6%（166/194）患者合并宫颈HPV感染，其中低危型感染者61.4%（119/194），高危型感染率高达23.7%（46/194）。外阴和宫颈皮损HPV型别的一致性达到95.8%（159/166），低危型HPV感染率从高到低依次为HPV11>HPV6>HPV53，高危型依次为HPV16>HPV18>HPV52>HPV31 >HPV45、HPV58。结论 上海地区女性外阴高危型HPV感染率较高，且近1/4患者合并宫颈高危型HPV感染；提示皮肤科医生应关注和加强女性尖锐湿疣患者宫颈高危型HPV感染情况与严密随访，这将对降低女性宫颈癌发生率有着极其重要的意义。

关键词: 尖锐湿疣, 人乳头瘤病毒, 宫颈肿瘤

Abstract:

[Abstract] Objective: To study the relationship between vulvar condylomata acuminata lesion and cervical HPV infection in female patients of Shanghai area. Methods: HPV DNA typing of 194 specimens from acuminata lesions and cervical cell collections was performed using hybridization and gene chip techniques. Results: HPV were detected in all 194 patients (100%). Among them, LR-HPV and HR-HPV infection was 74.2% (144/194) and 25.8% (50/194), respectively. LR-HPV infection was mainly characterized as a single HPV type (94.4%, 136/144) – either HPV6 or HPV11. In contrast, 86% (43/50) of HR-HPV infection were mixed with LR-HPV. Cervical cell examination showed that 85.6% (166/194) of patients were accompanied with HPV infection (LR = 61.4%, HR = 23.7%). In term of HPV type, the correlation between acuminata lesion and the cervix was 95.8%. The order of LR-HPV was HPV11>HPV6>HPV53 and that of HR-HPV was HPV16>HPV18>HPV52>HPV31 >HPV45 and HPV58. Conclusions: The infection rate of HR-HPV was high among female acuminata patients in Shanghai area and 1/4 of them were accompanied with HR-HPV infection of cervix. Therefore, dermatologists should pay attention to such infection in order to reduce the cervical cancer associated with HR-HPV infection.

Key words: Condyloma Acuminatum, Human papilloma virus