中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (6): 411-412.

• 临床经验 • 上一篇    下一篇

复方氟米松软膏与丙酸氯倍他索乳膏治疗慢性湿疹和神经性皮炎疗效对比研究

尹光文   

  1. 郑州大学第一附属医院皮肤科
  • 收稿日期:2007-09-18 修回日期:2007-10-20 发布日期:2008-06-15
  • 通讯作者: 尹光文 E-mail:yinguangwen1967@yahoo.com.cn

Efficacy of compound flumetasone ointment vs clobetasol cream in the treatment of chronic eczema and neurodermatitis

  • Received:2007-09-18 Revised:2007-10-20 Published:2008-06-15

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摘要： [摘要] 目的 观察奥深治疗慢性湿疹和神经性皮炎的临床疗效和不良反应。方法 151例慢性湿疹和神经性皮炎患者随机分为奥深治疗组76例（其中慢性湿疹45例，神经性皮炎31例），丙酸氯倍他索乳膏对照组75例（其中慢性湿疹43例，神经性皮炎32例），分别观察治疗后1、2、3周的临床疗效和不良反应。结果 治疗组和对照组治疗1周后的临床痊愈率分别为13.16 %和6.67%，两组比较无统计学差异（P>0.05），治疗组治疗后2、3周的临床痊愈率分别为53.95%和63.16%，对照组治疗后2、3周的临床痊愈率分别为28.00%和37.33 %，两组比较差异有统计学意义（P<0.05）；治疗组治疗后1、2、3周的临床有效率分别为43.42%，84.21%和92.11%，对照组治疗后1、2、3周的临床有效率分别为18.67 %，60.00%和69.33%，两组临床有效率比较差异均有统计学意义（P<0.05）。且未见有明显临床意义的不良反应。结论 奥深治疗慢性湿疹和神经性皮炎的疗效优于丙酸氯倍他索乳膏，无明显的不良反应，是治疗慢性湿疹和神经性皮炎较为理想药物。

关键词: 慢性湿疹, 神经性皮炎, 奥深, 复方氟米松软膏, 丙酸氯倍他索乳膏

Abstract: 【Abstract】Objective: To investigate the clinical efficacy and adverse effect of orsalin ointment to treat chronic eczema and neurodermatitis. Methods: 152 patients with chronic eczema and neurodermatitis were randomly assigned to two groups: one was a treatment group including 76 patients being treated with orsalin ointment (45 cases with chronic eczema and 31 cases with neurodermatitis), another was a control group including 75 patients being treated with clobetasol propionate (43 cases with chronic eczema and 32 cases with neurodermatitis).The Therapeutic efficacy and adverse effect was evaluated after treating one week,two weeks and three weeks. Results :After one week’s treatment, the healing rate was 13.16 % in the treatment group and 6.67% in the control group, there was no significant difference between the two groups(P>0.05). After two and three weeks’ treatment, the healing rate was 53.95% and 63.16% in the treatment group respectively, while that of control group was 28.00% and 37.33 % respectively, there was a significant difference between the two groups(P<0.05).The clinical effective rate of treatment group was 43.42%, 84.21% and 92.11% respectively as compared with that of control group was 18.67%,60.00% and 69.33% respectively, there was a significant difference both in the two groups (both P<0.05) and no obvious side effect was found in the two groups. Conclusion: orsalin ointment is a more suitable dermatologic topical preparation in the treatment of chronic eczema and neurodermatitis.

Key words: Chronic eczema, Neurodermatitis, orsalin ointment, Compound Flumetasone ointment, Clobetasol propionate