中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (9): 558-559.

• 论著 • 上一篇    下一篇

大疱性类天疱疮患者血清几种趋化因子的检测

袁艳霞, 林麟, 冯素英, 周武庆, 吴建兵   

  1. 中国医学科学院皮肤病研究所, 南京 210042
  • 收稿日期:2006-12-13 出版日期:2007-09-15 发布日期:2007-09-15
  • 通讯作者: 林麟, email:linlin2003@medmail.com.cn E-mail:linlin2003@medmail.com.cn

Serum levels of several chemokines in patients with bullous pemphigoid

YUAN Yan-xia, LIN Lin, FENG Su-ying, ZHOU Wu-qing, WU Jian-bing   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210042, China
  • Received:2006-12-13 Online:2007-09-15 Published:2007-09-15

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摘要： 目的 探讨大疱性类天疱疮(BP)患者CC型趋化因子家族中嗜酸粒细胞趋化因子(eotaxin)、调节激活正常T细胞表达和分泌的细胞因子(RANTES)、单核细胞趋化蛋白-l(MCP-1)和巨噬细胞炎症蛋白(MIP-lα)的表达.方法 用双抗体夹心ELISA方法检测28例活动期BP患者与30例正常人对照血清eotaxin、RANTES、MCP-1和MIP-lα水平.结果 BP患者血清eotaxin和MCP-1明显高于正常人,P分别<0.001,0.05.RANTES和MIP-lα水平与正常人比较差异无统计学意义(P均>0.05).结论 BP发病中存在趋化因子的异常,eotaxin和MCP-1可能与BP的发病有关.

关键词: 类天疱疮, 大疱性, 炎症趋化因子类

Abstract: Objective To investigate the serum levels of several CC chemokines,including eotaxin, RANTES(regulated upon activation,normal T cell expressed and secreted),monocyte chemoattractant protein-1(MCP-1)and macrophage inhibitory protein-1α(MIP-1α) in patients with bullous pemphigoid (BP).Methods Serum samples were collected from 28 patients with active BP and 30 healthy controls. ELISA was applied to measure the serum levels of the four chemokines.Results The serum levels of eotaxin and MCP-1 were significantly increased in patients with BP compared with those in the controls(487.45±116.32 vs 208.67±63.16 pg/mL,P<0.01;268.94±222.27 vs 158.29±42.17 pg/mL,P<0.05).No significant difference was observed in the levels of either of the other two chemokines between the patients and controls(P>0.05).Conclusions The serum levels of chemokines are abnormal in patients with BP,and eotaxin and MCP-1 may be involved in the pathogenesis of BP.

Key words: Pemphigoid,bullous, Chemokines