中华皮肤科杂志

• 论著 • 上一篇    下一篇

磷酸化Stat3和磷酸化Akt及磷酸化ERK1/2在表皮良恶性肿瘤中的表达

连昕, 林能兴, 涂亚庭   

  1. 华中科技大学同济医学院附属协和医院皮肤科, 武汉, 430022
  • 收稿日期:2006-10-23 出版日期:2007-07-15 发布日期:2007-07-15
  • 通讯作者: 连昕,email:xhchuqi@sina.com E-mail:xhchuqi@sina.com

Expression of phosphorylated-Stat 3,phosphorylated-Akt and phosphorylated-ERK1/2 in benign and malignant epidermal tumors

LIAN Xin, LIN Neng-xing, TU Ya-ting   

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2006-10-23 Online:2007-07-15 Published:2007-07-15

PDF (PC)

98

赞

摘要： 目的 探讨磷酸化细胞信号传导与转录活化因子3(p-Stat3)和磷酸化Akt(p-Akt)及磷酸化细胞外信号调节激酶(p-ERK1/2)在表皮良恶性肿瘤中的表达.方法 采用免疫组化的方法检测脂溢性角化病,光线性角化病,鲍恩样丘疹病,基底细胞上皮瘤,鲍恩病,鳞状细胞癌中p-Stat3,p-Akt及p-ERK1/2的表达.结果 p-Stat3,p-Akt及p-ERK1/2阳性表达率在表皮恶性肿瘤中明显高于良性肿瘤(P均<0.05).p-Stat3和p-Akt的阳性表达率在表皮恶性肿瘤中从高到低依次为鳞状细胞癌>鲍恩病>基底细胞上皮瘤,而p-ERK1/2的阳性表达率无差异(P>0.05).在表皮恶性肿瘤中,p-Stat3和p-Akt的阳性表达呈显著正相关(P<0.05).而p-ERK1/2的阳性表达与p-Star3、p-Akt的阳性表达之间无相关性(P>0.05).结论 p-Stat3,p-AKT和p-ERK1/2参与表皮恶性肿瘤的发病.

关键词: STAT3转录因子, 蛋白质丝氨酸苏氨酸激酶, 丝裂原活化蛋白激酶1, 表皮良恶性肿瘤

Abstract: Objective To investigate the expression ofp-Stat3,p-Akt and p-ERK1/2 in benign and malignant epidermal tumors.Methods Immunohistochemistry SP method was used to detect the expression of p-Stat3,p-Akt and p-ERK1/2 in specimens from 20 cases of seborrheic keratosis(SK),20 cases of actinic keratosis(AK),20 cases of bowenoid papulosis(BP),20 cases of basal cell carcinoma(BCC),20 cases of Bowen's disease(BD)and 50 cases of squamous cell carcinoma(SCC).Results The expression rates of p-Stat3,p-Akt and p-ERK1/2 were significantly higher in malignant epidermal tumors than those in benign epidermal tumors(all P<0.05).In malignant tumors,the expression rates of p-Stat3 and p-Akt were in decreasing order in SCC,BD and BCC,while the expression of p-ERK1/2 was of no significant difference(P>0.05).There was a positive correlation between the expression of p-Stat3 and p-Akt(P<0.05),but the expression of p-ERK1/2 did not correlate with that of p-Stat3 and p-Akt(both P>0.05). Conclusion p-Stat3,p-Akt and p-ERK1/2 may take part in the pathogenesis of malignant epidermal tumors.

Key words: STAT3 transcription factor, Protein-serine-threonine kinases, Mitogen-activated protein kinase 1, Benign and malignant tumors of epidermis