中华皮肤科杂志

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特应性皮炎患者血浆中P物质的测定及其临床意义

付瑶1, 高明阳1, 谷玲2   

  1. 1. 大连医科大学附属第一医院皮肤科, 116011;
    2. 大连医科大学附属第一医院核医学科, 116011
  • 收稿日期:2006-09-04 出版日期:2007-07-15 发布日期:2007-07-15
  • 通讯作者: 高明阳,email:dlgaomingyang@126.com E-mail:dlgaomingyang@126.com

Detection of substance P in patients with atopic dermatitis and its significance

FU Yao1, GAO Ming-yang1, GU Ling2   

  1. Department of Dermatology, First Hospital of Dalian Medical University, Dalian 116011, China
  • Received:2006-09-04 Online:2007-07-15 Published:2007-07-15

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摘要： 目的 探讨特应性皮炎患者血清中P物质水平及其临床意义.方法 用放射免疫法测定35例特应性皮炎患者血浆中P物质浓度,观察P物质与疾病严重程度积分及嗜酸粒细胞数的关系.结果 特应性皮炎患者血浆中P物质浓度明显高于正常人对照P<0.01),且疾病的EASI评分和Rajka严重度积分与P物质浓度呈显著正相关,r分别为0.95和0.86,P均<0.01.特应性皮炎患者外周血嗜酸粒细胞数明显高于正常人对照(P<0.01),并且与疾病的严重度呈正相关(与EASI评分r=0.42,P=0.011,与Rajka严重度积分r=0.42,P=0.013):特应性皮炎患者血浆中P物质浓度与外周血嗜酸粒细胞数呈正相关(r=0.43,P=0.009).结论 P物质对判断特应性皮炎活动性可能有一定价值;P物质可能与嗜酸粒细胞共同参与特应性皮炎发病.

关键词: 皮炎, 特应性, P物质

Abstract: Objective To explore the serum level of substance P and its clinical significance in patients with atopic dermatitis(AD).Methods The plasma level of substance P was measured by radioimmunoassay(RIA)in 35 patients with AD and 24 healthy controls.The correlation of substance P level with the disease severity[eczema area and index(EASI)score and Rajka scores]and eosinophil count was assessed.Results The plasma level of substance P was significantly higher in AD patients than that in normal controls(P<0.01),and positively correlated with the EASI score and Rajka score(r=0.95,0.86 respectively,both P<0.01).The eosinophil count in peripheral blood was also increased in AD patients as compared with that in the controls,and positively correlated with the EASI score and Rajka score(both r=0.42,P<0.05).A positive correlation was also found between the plasma level of substance P and eosinophil count in AD patients(r=0.43,P<0.05).Conclusion s Substance P may be a useful parameter in the evaluation of AD activity,and it may participate in the pathogenesis of AD by interacting with eosinophils.

Key words: Dermatitis,atopic, Substance P