中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (4): 199-201.

• 论著 • 上一篇    下一篇

大疱性类天疱疮疾病严重程度与BP180抗体水平关系的研究

冯素英, 靳培英, 林麟, 吴勤学, 周武庆, 桑红桂   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京, 210042
  • 收稿日期:2006-06-08 出版日期:2007-04-15 发布日期:2007-04-15
  • 通讯作者: 林麟,email:lin1in2003@medmail.com.cn E-mail:lin1in2003@medmail.com.cn

Correlation of disease severity with serum titer of anti-BP180 autoantibody in patients with bullous pemphigoid

FENG Su-ying, JIN Pei-ying, LIN Lin, WU Qin-xue, ZHOU Wu-qing, SANG Hong-gui   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210442, China
  • Received:2006-06-08 Online:2007-04-15 Published:2007-04-15

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摘要： 目的 研究大疱性类天疱疮患者临床疾病严重程度和BP180抗体滴度之间的关系.方法 用BP180NC16a-ELISA分别测定大疱性类天疱疮患者治疗前,病情缓解、糖皮质激素开始减量时和糖皮质激素减量至相当于泼尼松0.5 mg·kg-1·d-1时,体内BP180抗体滴度,观察其与患者病情严重程度的一致性.结果 在治疗前,19例大疱性类天疱疮患者的BP180 ELISA平均A值为0.520(0.832～0.372);在病情得到控制、糖皮质激素准备减量时,其BP180 ELISA平均A值为0.405(O.723～0.204);在病情缓解、糖皮质激素减至相当于泼尼松0.5 mg·kg-1·d-1时,其BP180 ELISA平均A值为0.215(0.412～0.093).结论 BP180抗体的滴度与大疱性类天疱疮患者疾病严重程度相关,是一种评估疾病病情的有用手段,也可对治疗的有效性作出评价.

关键词: 白癜风, 甲状腺球蛋白抗体, 甲状腺过氧化物酶抗体, 自身免疫甲状腺病, 类天疱疮,大疱性, 自身抗体:BP180, 疾病严重程度

Abstract: Objective To investigate the correlation of disease severity with serum titer of anti-BP180 autoantibody in patients with bullous pemphigoid(BP).Methods Twenty patients were enrolled into the study.Blood samples were collected 3-4 times at different stages of treatment process from every patient.Serum titer of anti-BP180 autoantibody was measured with BP180NC16a-ELISA.Correlation analysis of ELISA indices with disease severity was performed.Results Out of the 20 BP patients,19 were positive for anti-BP180 antibody.Mean ELISA OD value of the 19 patients was 0.520(range:0.832-0.372) before treatment,0.405(range:0.723-0.204) when disease was under control and glucocorticosteroid dosage was ready to be reduced,and 0.215(range:0.412-0.093) when glucocorticosteroid dosage was successfully tapered to 0.5 mg·kg-1·d-1 of prednisone equivalent.Compared with ELISA indices before treatment,they were significantly reduced after successful therapy(P<0.001).Conclusions Serum titer of anti-BP180 autoantibody is well correlated with disease severity in BP patients.So,it may be used to evaluate the disease severity of and therapeutic effect on BP.

Key words: Pemphigoid,bullous, Autoantibadies, BP 180, Clinical severity