中华皮肤科杂志

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尖锐湿疣患者外周血CD8+T细胞细胞因子的表达

刘冬先1, 江文1, 陈兴平1, 陈映玲1, 杨东亮2   

  1. 1. 华中科技大学同济医学院附属同济医院皮肤科, 武汉430030;
    2. 华中科技大学同济医学院临床免疫室, 武汉430030
  • 收稿日期:2006-12-26 出版日期:2007-11-15 发布日期:2007-11-15
  • 作者简介:刘冬先(email:DXliu@tjh.tjmu.edu.cn)

Expression of cytokines in CD8+ T lymphocytes of the peripheral blood of patients with condyloma acuminatum

LIU Dong-xian1, JIANG Wen1, CHEN Xing-ping1, CHEN Ying-ling1, YANG Dong-liang2   

  1. Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2006-12-26 Online:2007-11-15 Published:2007-11-15

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摘要： 目的 检测尖锐湿疣患者外周血CD8+T细胞白介素-2、白介素-12、干扰素-γ、白介素-4的表达水平,探讨其在尖锐湿疣发病中的作用.方法 应用流式细胞仪检测60例尖锐湿疣患者和20例正常人对照者外周血CD8+T细胞白介素-2、白介素-12、干扰素-γ、白介素-4的表达水平.结果 尖锐湿疣患者外周血CD8+T细胞白介素-2、白介素-12、干扰素-γ阳性细胞百分比均显著下降(P<0.01);白介素-4+CD8+T细胞百分比与正常人对照组比较,差异无统计学意义(P>0.05);干扰素-γ+/白介素-4+T细胞比值显著低于正常人对照组(P<0.01).结论 尖锐湿疣患者Tc1细胞水平低下,Tc1/Tc2显著低于正常人对照.

关键词: 尖锐湿疣, CD8阳性T淋巴细胞, 细胞因子类

Abstract: Objective To detect the levels of cytokine IL-2,IL-12,IFN-γand IL-4 secreted by peripheral CD8+ T lymphocytes in patients with condyloma acuminatum (CA).Methods Flow cytometry was employed to study the expression of cytokines IL-2,-12,INF-γand IL-4 in CD8+ T lymphocytes in the peripheral blood of 60 patients with CA and 20 healthy controls.Results The percentage of CD8+ T lymphocytes producing IL-2,IL-12 and IFN-γwere significantly lower in CA patients than that in healthy controls (P<0.001),while the percentage of IL-4-producing CD8+ T lymphocytes was of no significant difference between two groups.The ratio of Tc1/Tc2 was also decreased in CA patients as compared with the healthy controls (P<0.001).Conclusion The quantity of Tc1 cells and the ratio of Tc1/Tc2 are significantly lower in CA patients than those in healthy controls.

Key words: Condylomata acuminata, CD8 positive T-lymphocytes, Cytokines