中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (3): 137-139.

• 论著 • 上一篇    下一篇

5-氨基酮戊酸乳膏光动力疗法治疗皮肤癌前病变和皮肤原位癌

王宏伟, 王秀丽, 过明霞, 虞叶风   

  1. 上海市皮肤病性病医院, 200050
  • 收稿日期:2005-06-15 出版日期:2006-03-15 发布日期:2006-03-15

Topical 5-aminolaevulinic acid-photodynamic therapy in the treatment of precancerous changes and carcinoma of the skin in situ

WANG Hong-wei, WANG Xiu-li, GUO Ming-xia, YU Ye-feng   

  1. Shanghai Skin Diseases & STD Hospital, Shanghai 200050, China
  • Received:2005-06-15 Online:2006-03-15 Published:2006-03-15

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摘要：

目的 探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗皮肤癌前病变和皮肤原位癌的疗效.方法 对15例光线性角化病、3例Queyrat增生性红斑和8例Bowen病患者进行ALA-PDT治疗.结果 15例光线性角化病患者的17个皮损获得完全缓解,2例复发,复发率13.33%;3例Queyrat增生性红斑除1例无效外,另2例患者的皮损获完全缓解,无复发;8例Bowen病除1例获得部分缓解外,其他7例完全缓解,1例复发.结论 ALA-PDT是一种疗效好、无明显痛苦、无瘢痕形成、复发率低、美容效果好的治疗皮肤癌前病变和皮肤原位癌的新疗法;特别适合于头面部及外生殖器部位的多发性、较大面积皮损.

关键词: 氨基酮戊酸, 角化病, 增殖性红斑, Bowen病

Abstract:

Objective To investigate the effects of 5-aminolaevulinic acid-photodynamic therapy (ALA-PDT) on precancerous changes and carcinoma of the skin in situ. Methods Fifteen patients with actinic keratosis, 3 patients with erythroplasia of Queyrat and 8 patients with Bowen's disease were given topical ALA followed by PDT. Results The clearance was achieved in 17 lesions of 15 patients with actinic keratosis, 2 patients with erythroplasia of Queyrat and 7 patients with Bowen's disease by topical ALA-PDT. The recurrence rates were 13.33%, 0 and 14.28% for actinic keratosis, erythroplasia of Queyrat and Bowen's disease, respectively. Conclusions Topical ALA-PDT is a simple, effective and new treatment with lower recurrent rates, no scar formation and excellent cosmetic Resultsfor precancerous changes and carcinoma in situ of the skin, especially for the large and multifocal lesions located on the face and external genitalia.

Key words: Aminolevulinic acid, Keratosis, Erythroplasia, Bowen’s disease