中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (6): 354-356.

• 论著 • 上一篇    下一篇

特应性皮炎和湿疹患者血清白介素4和干扰素γ水平的检测

郭庆1, 曾凡钦1, 毕志刚2, 张美华2, 弓娟琴3, 陈敏3, 钟白玉4, 郝飞4, 赵辨2   

  1. 1. 中山大学附属第二医院皮肤科 广州 510120;
    2. 江苏省人民医院皮肤科;
    3. 中国医学科学院、中国协和医科大学皮肤病研究所;
    4. 第三军医大学西南医院皮肤科
  • 收稿日期:2004-08-07 出版日期:2005-06-15 发布日期:2005-06-15
  • 通讯作者: 赵辨,E-mail:zhaobian@sina.com E-mail:zhaobian@sina.com

Detection and Analysis of Serum Levels of Interleukin-4 and Interfero n-gamma in Patients with Atopic Dermatitis and Eczema Before and After Treatment

GUO Qing1, ZENG Fan-qin1, BI Zhi-gang2, ZHANG Mei-hua2, GONG Juan-qin3, CHEN Ming3, ZHONG Bai-yu4, HAO Fei4, ZHAO Bian2   

  1. Department of Dermatology, The 2nd Affiliated Hospital, Zhongshan University, Guangzhou 510120, China
  • Received:2004-08-07 Online:2005-06-15 Published:2005-06-15

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摘要： 目的 探讨血清白介素4(IL-4)和干扰素γ(IFN-γ)水平变化在特应性皮炎、湿疹发病机制中的作用,以及糖皮质激素联合抗生素(治疗组)和单独糖皮质激素(对照组)外用治疗前后两种细胞因子的变化。方法 采用双抗体夹心ELISA法检测治疗前后患者血清IL-4和IFN-γ水平 结果 特应性皮炎、湿疹患者IL-4、IFN-γ水平明显高于正常人对照(P<0.05)。治疗28d后,治疗组IL-4水平明显下降(P<0.05),而IFN-γ无明显变化;对照组两种细胞因子水平变化无统计学意义(P>0.05)。结论 特应性皮炎、湿疹患者存在循环IL-4和IFN-γ水平明显异常。糖皮质激素联合抗生素外用治疗特应性皮炎、湿疹可干扰IL-4水平取得较好疗效,较单独外用糖皮质激素疗效显著。

关键词: 皮炎,特应性, 湿疹, 白细胞介素4, 干扰素Ⅱ型

Abstract: Objectives To study the role of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) in the pathogenesis of atopic dermatitis and eczema,and the changes of serum levels of IL-4 and INF-γ with topical treatment of corticosteroid plus antibiotic cream or corticosteroid cream alone. Methods Serum levels of IL-4 and IFN-γ were detected by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-4 and INF-γ were significantly higher in the patients with atopic dermatitis and eczema than those in the normal controls,respectively(both P<0.05).In the study group after a 28-day treatment with corticosteroid plusantibiotic cream,serum levels were significantly decreased for IL-4 (P<0.05)and were no changes for INF-γ.Neither of the two cytokines was changed after the treatment in the controls. Conclusions Both atopic derm atitis and eczema are characterised by abnormality in serum levels of circulatin g IL-4 and INF-γ.Treatment with corticosteroid plus antibiotic creamseems more effective,which might influence serum IL-4 level,than that with corticostero id cream alone in atopic dermatitis and eczema.

Key words: Interferon type Ⅱ, Interleukin-4, Dermatitis, atopic, Eczema