中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (4): 222-224.

• 论著 • 上一篇    下一篇

马拉色菌与花斑癣色素改变的相关性初探

陶诗沁1, 陈炜2, 杨莉佳1, 陈伟2, 张海萍1, 吕桂霞2, 刘维达2   

  1. 1. 江苏省无锡市第二人民医院皮肤科 214002;
    2. 中国医学科学院, 中国协和医科大学皮肤病研究所真菌科
  • 收稿日期:2004-04-09 出版日期:2005-04-15 发布日期:2005-04-15

Preliminary Study on the Pigmentogenesis of Malassezia in Pityriasis Versicolor

TAO Shi-qin1, CHEN Wei2, YANG Li-jia1, CHEN Wei2, ZHANG Hai-ping1, LÜ Gui-xia2, LIU Wei-da2   

  1. Department of Dermatology, Wuxi People's No.2 Hospital, Wuxi 214002, China
  • Received:2004-04-09 Online:2005-04-15 Published:2005-04-15

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摘要： 目的 探讨马拉色菌与花斑癣皮疹色素改变及色氨酸产色三者之间的关系。方法 从花斑癣患者皮损分离马拉色菌株,采用国际通用的生化鉴定方法鉴定,然后在不同浓度L-色氨酸的培养基上培养7d,观察产色反应。结果 每个菌种均有产色反应阳性和阴性菌株,产色反应阳性菌株更易引起皮损色素沉着(P<0.005),且产色反应阳性标本颜色按色氨酸浓度递减而变淡。结论 菌株的产色反应与马拉色菌的种属分类无必然的联系,色氨酸参与了马拉色菌产色反应。

关键词: 癣,花斑, 马拉色霉菌属, 色氨酸

Abstract: Objective To investigate the relationship among the pigment change in the skin lesions of pityriasis versicolor, the tryptophan-induced pigment production, and the 7 species of Malassezia. Methods 171 strains of 7 species of Malassezia were isolated from the patients with pityriasis versicolor, and identified by the internationally used biochemical tests. The strains were then cultured on the media with 4 different concentrations of L-tryptophan for 7 days. The degree of pigment production was observed. Results Positive- and negative- pigment-producing strains were observed in all the 7 species. The degree of the pigment production was positively correlated with the concentration of L-tryptophan. The positive-pigment-producing strains were prone to cause the pigmentation in the skin lesion of pityriasis versicolor (P<0.005). Conclusions The pigment production has no relationship with the species of Malassezia. L-Tryptophan is involved in the pigment production of Malassezia.

Key words: Tinea versicolor, Malassezia, Tryptophan