中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (12): 748-750.

• 论著 • 上一篇    下一篇

恶性黑素瘤和普通痣细胞痣组织中双链RNA依赖的蛋白激酶的表达

高滢, 李春英, 马翠玲, 殷河慧, 高天文   

  1. 第四军医大学西京医院全军皮肤性病中心 西安 710032
  • 收稿日期:2004-12-27 发布日期:2005-12-15
  • 通讯作者: 高天文,E-mil:gaotw@fmmu.edu.cn E-mail:gaotw@fmmu.edu.cn

Expression of Double-stranded RNA-dependent Protein Kinase in Malignant Melanoma and Ordinary Nevi

GAO Ying, LI Chun-ying, MA Cui-ling, YIN He-hui, GAO Tian-wen   

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
  • Received:2004-12-27 Published:2005-12-15

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摘要： 目的 探讨恶性黑素瘤和普通痣细胞痣组织中双链RNA依赖的蛋白激酶(PKR)的表达情况,并分析PKR与恶性黑素瘤的细胞增殖程度及临床病理参数的关系。方法 应用免疫组化法检测42例恶性黑素瘤及25例普通痣细胞痣组织中PKR及增殖细胞核抗原的表达。结果 恶性黑素瘤中PKR阳性表达率显著高于普通痣细胞痣组织。恶性黑素瘤中PKR的表达水平与增殖细胞核抗原的表达呈显著负相关;与患者性别、年龄、有无淋巴结转移及TNM分级等临床病理特征均无明显相关性。结论 PKR在恶性黑素瘤细胞增殖过程中具有重要作用。

关键词: 黑色素瘤, 痣, eIF-2激酶, 增殖细胞核抗原

Abstract: Objective To study the expression of double-stranded RNA-dependent protein kinase (PKR) in malignant melanoma and ordinary nevi. Methods The expression of PKR and proliferating cell nuclear antigen was examined in 42 cases of malignant melanoma and 25 ordinary nevi by an immunohistochemical method. Results The positive rate of PKR expression was higher in the patients with malignant melanoma than that in the patients with ordinary nevi (P<0.001). In malignant melanoma, the expression of PKR inversely correlated with that of proliferating cell nuclear antigen (r=-0.442, P<0.001). The expression of PKR was unrelated to the clinical features in malignant melanoma. Conclusion PKR may play an important role in the cellular proliferation of malignant melanoma.

Key words: Melanoma, Nevus, eIF-2 kinase, Proliferating cell nuclear antigen