中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (11): 665-667.

• 论著 • 上一篇    下一篇

β联蛋白和淋巴样增强因子1在恶性黑素瘤中的表达

殷河慧, 廖文俊, 高滢, 高天文   

  1. 第四军医大学西京医院、全军皮肤性病中心, 西安 710032
  • 收稿日期:2004-12-17 发布日期:2005-11-15
  • 通讯作者: 廖文俊, E-mail:liaowenjun@263.net E-mail:liaowenjun@263.net

Expression of β-Catenin and LEF-1 in Malignant Melanoma

YIN He-hui, LIAO Wen-jun, GAO Ying, GAO Tian-wen   

  1. Center of Dermatology of the Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
  • Received:2004-12-17 Published:2005-11-15

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摘要： 目的 探讨β联蛋白、淋巴样增强因子1在恶性黑素瘤中的表达及意义.方法 采用免疫组化PowerVisionTM二步法检测25例皮内痣、45例恶性黑素瘤中β联蛋白、淋巴样增强因子1的表达情况.结果 β联蛋白在恶性黑素瘤中异常表达率为73%,皮内痣为36%,两组差异有统计学意义;淋巴样增强因子1在恶性黑素瘤中阳性表达率为62.2%,皮内痣组为0,两组差异有统计学意义.肿瘤组织中淋巴样增强因子1高表达率与淋巴结转移、TNM分期密切相关(P<0.05),而β联蛋白异常表达率与淋巴结转移及TNM分期无明显关系;β联蛋白异常表达与淋巴样增强因子1高表达之间存在正相关(P<0.05).结论 β联蛋白、淋巴样增强因子1异常表达可能与恶性黑素瘤发病相关.

关键词: 黑色素瘤, β联蛋白, 淋巴样增强因子1

Abstract: Objective To investigate β-catenin and lymphoid enhancing factor 1 (LEF-1) expression in malignant melanoma. Methods β-catenin and LEF-1 protein expression was examined using the PowerVisionTM immunohistochemical method in 25 cases of intradermal nevus and 45 cases of malignant melanoma. Results Comparing malignant melanoma with intradermal nevi, there was a significant difference in the expression of β-catenin (33/45=73% vs. 9/25=36%, respectively;P<0.05) and the expression of LEF-1 (28/45=62.2% vs. 0/25=0%, respectively;P<0.05). LEF-1 expression was correlated with lymphatic metastasis and TNM staging (P<0.05), while β-catenin expression was not. In cancer tissues, the abnormal expression of β-catenin was positively correlated with LEF-1 expression (P<0.05). Conclusion The abnormal expression of β-catenin and LEF-1 may play an important role in the carcinogenesis and progression of malignant melanoma.

Key words: Melanoma, β-catenin, Lymphoid enhancing factor