中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (5): 290-292.

• 论著 • 上一篇    下一篇

硝酸益康唑与六种抗菌药物体外抗菌活性的比较

赵辨1, 赵旺胜2, 梅亚宁2, 文怡2, 戎国栋2, 张晓军1   

  1. 1. 南京医科大学第一附属医院皮肤科, 210029;
    2. 南京医科大学第一附属医院临床检验中心, 210029
  • 收稿日期:2003-11-28 出版日期:2004-05-15 发布日期:2004-05-15

Comparison of in Vitro Antimicrobial Activity of Econazole with other Six Antibacterial Drugs

ZHAO Bian1, ZHAO Wang-sheng2, MEI Ya-ning2, WEN Yi2, RONG Guo-dong2, ZHANG Xiao-jun1   

  1. The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
  • Received:2003-11-28 Online:2004-05-15 Published:2004-05-15

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摘要： 目的 评价益康唑的抗葡萄球菌效果。方法 222株从湿疹及特应性皮炎患者皮损处分离出的葡萄球菌,采用肉汤稀释法测定对新霉素、红霉素、青霉素、头孢噻肟钠、环丙沙星及阿米卡星的最小抑菌浓度。结果 对甲氧西林敏感的金葡菌的MIC50值,益康唑与新霉素、环丙沙星、阿米卡星、头孢噻肟钠相近,低于青霉素与红霉素。对甲氧西林耐药的金葡菌的MIC50明显低于其他6种抗菌药物。对甲氧西林敏感且凝固酶阴性葡萄球菌的MIC50与阿米卡星、环丙沙星、青霉素相同,低于新霉素、头孢噻肟钠、红霉素。对甲氧西林耐药凝固酶阴性葡萄球菌的MIC50与阿米卡星、环丙沙星、青霉素、新霉素相近,低于头孢噻肟钠、红霉素。根据NCCLS标准显示:环丙沙星、青霉素、红霉素无论对金葡菌还是对凝固酶阴性葡萄球菌的耐药率均相当高。阿米卡星及头孢噻肟钠对甲氧西林敏感株的耐药率较低,但对甲氧西林耐药株高至50%以上。益康唑的MIC50与MIC90值相近。而新霉素的MIC50与MIC90值相差很大,其MIC90值则远高于益康唑。结论 益康唑对金葡菌及凝固酶阴性葡萄球菌均有明显的抗菌效果。益康唑的MIC50与MIC90值相近,未出现对益康唑的耐药现象。

关键词: 益康唑, 抗生素类, 微生物敏感性试验

Abstract: Objective To assess the antimicrobial actitivity of econazole nitrate in comparison with other six antibacterial drugs. Methods The minimal inhibitory concentrations (MICs) of econazole nitrate (Eco), neomycin (Neo), erythromycin (E), penicillin (P), cefotaxime sodium (Cef), ciprofloxacin (Cip) and amikacin (An) to 222 strains of Staphylococcus spp isolated from the lesions of patients with eczema and atopic dermatitis were determined by using the broth dilution method. Results MIC50 values of Eco were similar to Neo, Cip, An and Cef, and lower than those of P and E on methicillin-sensitive Staphylococcus aureus (MSSA); significantly lower than those of the other six antibacterial drugs on methicillin-resistant Staphylococcus aureus (MRSA); similar to An, Cip and P, and lower than those of Neo, Cef and E on methicillin-sensitive and coagulase-negative Staphylococcus (MSCNS); and similar to An, Cip P or Neo, and lower than Cef and E on methicillin-resistant and coagulase negative Staphylococcus (MRCNS). Based on the NCCLS standards, the resistance rates of Cip, P and E were very high to either Staphylococcus areus or coagulase-negative Staphylococcus (CNS). The resistance rates of An and Cef of were lower to MSSA, but higher than 50% to MRSA. MIC90 value of Eco was similar to its MIC50, and lower than the MIC value reported in the literature. The MIC90 value of neomycin was muich higher than the MIC50 value of econazole. Conclusion Econazole nitrate has antibacterial activity to both Staphylococcus areus and CNS. MIC90 value of Eco is similar to its MIC50, and no resistance to Eco was found.

Key words: Econazole, Microbial sensitivity tests, Antibiotics