中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (5): 288-289.

• 论著 • 上一篇    下一篇

性病与HIV感染者中HSV2、HBsAg和HCV的检测

顾伟鸣1, 廖明敏2, 杨阳1, 吴磊1, 胡伟忠1   

  1. 1. 上海市皮肤病性病医院, 200050;
    2. University of Ottawa, Canada
  • 收稿日期:2003-05-26 出版日期:2004-05-15 发布日期:2004-05-15
  • 基金资助:
    上海市自然科学基金资助课题(D2ZB14084)

Detection of HSV2-IgG, HBsAg and HCV in Patients with STD and HIV Infection

GU Wei-ming1, LIAO Ming-min2, YANG Yang1, WU Lei1, HU Wei-zhong1   

  1. Shanghai Dermatosis and STD Hospital, Shanghai 200050, China
  • Received:2003-05-26 Online:2004-05-15 Published:2004-05-15

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摘要： 目的 比较性病患者和HIV感染者血清中单纯疱疹病毒(HSV)、乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)的感染情况,为采取综合性的防治方案提供参考依据。方法 对经蛋白印迹法确证的HIV(+)/AIDS库存血清标本和梅毒、淋病及衣原体感染患者血清标本,用ELISA方法同时检测HSV2-IgG、HSV2-IgM、HBsAg和HCV-IgG4项指标,并对2组标本的检测结果进行比较。结果 在76份性病样品中,检出HSV2-IgG24例占31.58%;HSV2-IgM1例占1.32%;HBsAg8例占10.53%和HCV1例占1.32%。在另外分组的14例HIV阳性标本中,检出HSV2-IgG7例占50.00%;HSV2-IgM5例占35.71%;HBsAg8例占57.14%和HCV3例占21.43%。在总共90份标本中,有6例标本同时检测到HSV和HBV;2例标本同时检出HSV-IgM和HBV;2例同时检出上述4项指标。统计分析发现,HIV(+)/AIDS组中HSV、HBV和HCV的检出率明显高于性病组(P<0.05)。结论 HIV(+)/AIDS患者中合并HSV、HBV及HCV的感染率明显高于其他性病患者。

关键词: 性传播疾病, HIV, 疱疹病毒2型,人, 肝炎病毒,乙型, 肝炎病毒,丙型

Abstract: Objectives To compare the co-infection statues of HSV, HBV and HCV in patients with STD and HIV infection for providing evidence of developing prevention and control strategies. Methods Serum samples confirmed to be infected with HIV/AIDS by Western blot, and serum samples of patients with STDs (syphilis, gonorrhoea and chlamydial infection) were tested for HSV2-IgG, HSV2-IgM, HBsAg and HCV-IgG by ELISA. The detection levels were compared between the two groups. Results Out of 76 specimens in STD group, HSV2-IgG was detected in 24 specimens (31.58%), HSV2-IgM in one specimen (1.32%), HBsAg positive in 8 (10.53%), and HCV antibody positive in 4 (1.32%). In 14 specimens of HIV/AIDS group, HSV2-IgG were detected in 7 (50.00%); HSV2-IgM in 5 (35.71%);8 (578.14%) were positive for HBsAg and 3 (21.43%) for HCV. In a total of 90 specimens, both HSV and HBV were detected in 6 specimens, both HSV-IgM and HBV in 2, and the four above-mentioned antibodies in 2. The infection rates of HSV, HBV and HCV were significantly higher in HIV-infected specimens than those in the STD specimens (P<0.05). Conclusion Co-infection of HSV, HBV and HCV in HIV/AIDS patients is higher than that of STD patients.

Key words: Sexually Transmitted Diseases, HIV, Herpesvirus 2, human, Hepatitis B virus, Hepatitis C virus