中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (2): 103-104.

• 论著 • 上一篇    下一篇

慢性荨麻疹患者甲状腺功能的研究

郑文军1, 林有坤1, 韦凤鲜2, 覃伟武2, 罗佐杰3, 潘尚领4   

  1. 1. 广西医科大学第一附属医院皮肤性病科 南宁 530021;
    2. 广西医科大学第一附属医院核医学科 南宁 530021;
    3. 广西医科大学第一附属医院内分泌科 南宁 530021;
    4. 广西医科大学病理生理学教研室 南宁 530021
  • 收稿日期:2003-02-17 出版日期:2004-02-15 发布日期:2004-02-15

The Association of Chronic Urticaria and Thyroid Autoimmunity

ZHENG Wen-jun1, LIN You-kun1, WEI Feng-xian2, QIN Wei-wu2, LUO Zuo-jie3, PAN Shang-ling4   

  1. Department of Dermatology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China
  • Received:2003-02-17 Online:2004-02-15 Published:2004-02-15

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摘要： 目的 探讨慢性荨麻疹与甲状腺功能的关系。方法 采用放射免疫法及ELISA对56例慢性荨麻疹患者及40例正常人对照组的甲状腺功能、甲状腺自身抗体及细胞因子进行检测。结果 56例患者中促甲状腺素(TSH)、抗甲状腺球蛋白抗体(TG-Ab)、抗甲状腺微粒体抗体(TM-Ab)异常的分别有8例、5例、7例,其水平均显著高于对照组(P均<0.05);白介素1(IL-1)、白介素8(IL-8),也显著高于对照组(P均<0.001),但两组的三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)及γ三碘甲腺原氨酸(γ-T3)相比,差异无显著性。结论 慢性荨麻疹的甲状腺功能、甲状腺自身抗体及细胞因子异常,提示部分患者的发病可能与甲状腺功能有关。

关键词: 荨麻疹, 甲状腺激素类, 免疫球蛋白类,甲状腺刺激, 白细胞介素1, 白细胞介素8

Abstract: Objective To investigate the role of thyroid autoimmunity in chronic urticaria. Methods The thyroid function, anti-thyroid auto-antibodies, and relevant cytokines were detected by RIA and ELISA methods in 56 patients with chronic urticaria and 40 healthy controls. Results Serum thyroid-stimulating hormone (TSH), anti-thyroglobulin antibody (TG-Ab) and anti-thyromicrosome antibody (TMA) levels were increased in 8, 5 and 7 cases, respectively, in 56 patients, which were significantly higher than those in healthy controls (P<0.05, 0.05, and 0.05, respectively). IL-1 and IL-8 levels were significantly increased in patients in comparison with those in controls (P<0.001). There were no significant differences of the levels of other parameters (T3, T4, FT3, FT4 and γ-T3) between two groups. Conclusion The data show that patients with chronic urticaria have abnormalities in thyroid function, anti-thyroid antibodies, and IL-1 and IL-8, suggesting that autoimmunity may be involved in the pathogenesis of chronic urticaria.

Key words: Urticaria, Thyroid hormones, Immunoglobulins, thyroid-stimulating, Interleukin-1, Intrtleukin-8