中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (12): 701-702.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者白介素13和神经生长因子的测定及其临床意义

陈艳蕾, 徐祖森   

  1. 华中科技大学同济医学院附属同济医院皮肤性病科 武汉 430030
  • 收稿日期:2003-12-10 出版日期:2004-12-15 发布日期:2004-12-15

Determination of Interleukin-13 and Nerve Growth Factor in Patients with Systemic Lupus Erythematosus and Its Significance

CHEN Yan-lei, XU Zu-sen   

  1. Department of Dermatology, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2003-12-10 Online:2004-12-15 Published:2004-12-15

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摘要： 目的 探讨系统性红斑狼疮(SLE)患者血清中白介素13和神经生长因子的水平变化.方法 应用酶联免疫吸附法检测35例SLE患者和15例正常人血清白介素13和神经生长因子水平.结果 SLE活动期患者血清白介素13水平为(92.69±9.87)pg/mL及神经生长因子水平为(339.69±25.60)pg/mL,SLE稳定期患者分别为(54.22±9.31)pg/mL和(300.89±33.51)pg/mL,正常人对照组分别为(35.20±12.70)pg/mL和(111.40±32.54)pg/mL.SLE活动期、稳定期患者血清白介素13和神经生长因子水平均显著高于正常人对照组(P<0.05或<0.01),SLE活动期显著高于稳定期(P值均<0.01).SLE患者血清白介素13水平与SLEDAI积分、血沉、C3均呈显著相关(r值分别为0.813、0.504、-0.605),神经生长因子水平与上述指标也呈显著相关(r值分别为0.442、0.338、-0.463),同时白介素13和神经生长因子水平呈显著正相关(r=0.506,P<0.01).结论 白介素13和神经生长因子在SLE的发病中可能发挥一定的作用.

关键词: 红斑狼疮,系统性, 白细胞介素13, 神经生长因子

Abstract: Objectives To investigate the serum levels of IL-13 and n erve growth factor (NGF) and their clinical significance in patients with system ic lupus erythematosus (SLE).Methods The serum levels of IL-13 and NGF were measured by ELISA in 35 SLE patients and 15 normal controls.Results The serum levels of IL-13 and NGF in patients with active SLE were both significantly high er than those in patients with inactive SLE (IL-13: 92.69±9.87 pg/mL versus 54.22±9.31 pg/mL, P<0.01; NGF: 339.69±25.60 pg/mL versus 300.89±33.51 pg/mL, P<0.01).The serum levels of IL-13 and NGF in patients with inactive SL E were also significantly higher than those in normal controls (IL-13: 54.22±9.31 pg/mL versus 35.20±12.70 pg/mL, P<0.05; NGF: 300.89±33.51 pg/mL ver sus 111.40±32.54 pg/mL, P<0.01).The serum levels of IL-13 and NGF were correlated with the disease activity index of SLE, ESR and the serum level of C3 (IL-13: r=0.813, 0.504,-0.605, respectively; NGF: r=0.442, 0.338,-0.463, respectively).There was also a positive correlation between the serum levels of IL-13 and NGF (r=0.506, P<0.01).Conclusion These results indicate that IL-13 and NGF may be involved in the pathogenesis of SLE and obviously correlated with the disease activity.

Key words: Lupus erythematosus,systemic, Interleukin-13, Nerve growth factor